ArticleFrontiers in neurology2022
Addition of high-intensity interval training to a moderate intensity continuous training cardiovascular rehabilitation program after ischemic cerebrovascular disease: A randomized controlled trial.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 12 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 12 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Nonlinear dose-response effects of exercise interventions on post-stroke depression: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Optimizing physical fitness in chronic stroke patients: the impact of exercise training modality and dosage on maximal and sub-maximal fitness - a systematic review and meta-analysis.Journal of rehabilitation medicine · 2025Pooled it
- Current exercise-based rehabilitation impacts on poststroke exercise capacity, blood pressure, and lipid control: a meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- The effect of exercise interventions on reducing the risk of depressive and cognitive disorders in post-stroke-a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Effects of high-intensity exercise on rehabilitation of patients after stroke: a systematic review and meta-analysis of randomized controlled trials with high quality.Frontiers in neurology · 2025Pooled it
- The safety and efficacy of high-intensity interval training (HIIT) in post-stroke patients with moderate functional impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Pooled it
- Network meta-analysis of non-pharmacological interventions for cognitive impairment after an ischemic stroke.Frontiers in neurology · 2024Pooled it
- Effects of exercise dose based on the ACSM recommendations on patients with post-stroke cognitive impairment: a systematic review and meta-analyses.Frontiers in physiology · 2024Pooled it
- Pooled it
- High-intensity interval training after stroke: a three-level random-effects meta-analysis with cluster-robust inference and exploratory dose-parameter signals.Frontiers in neurologyPooled it
- Comparative effectiveness of aerobic training intensities in chronic stroke: a network meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
- Article
- The Aphasia Physical EXercise (APEX) study: feasibility of a new high-intensity functional interval training for stroke survivors with aphasia.Aphasiology · 2026Article
- From Stroke to Strength: The Role of Exercise in Managing Hypertension and Lipid Profiles.Neurology and therapy · 2026Review
- Submaximal Exercise Testing to Dose High-Intensity Interval Training After Stroke: The FAST Randomized Clinical Trial.medRxiv : the preprint server for health sciences · 2026Article
- High-intensity interval training after stroke: evidence & practice.Physical activity and nutrition · 2026Article
- Optimal exercise modalities for enhancing motor function recovery after stroke: a Bayesian systematic review with pairwise and network meta-analyses.EClinicalMedicine · 2026Article
- Machine learning-based predictive model for post-stroke cardiorespiratory fitness.BMC neurology · 2026Article
- Targeting dyspnoea through exercise intensity: insights from pulmonary rehabilitation and beyond, a narrative review.Frontiers in rehabilitation sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Moderate intensity continuous training (MICT) is usually recommended for stroke or transient ischemic attack (TIA) patients. High intensity interval training (HIIT) has emerged as a potentially effective method for increasing cardiorespiratory fitness (CRF) among clinical populations. Its effectiveness remains to be demonstrated after stroke. A combined program of HIIT and MICT was designed to create a realistic exercise program implemented for a clinical setting to help patients become more active. Purpose: This study aimed to compare the effects of a 6-month exercise program with either MICT only or a combination of HIIT and MICT and a control group in terms of CRF, cardiovascular risk factors, functionality, cognitive function (Montreal Cognitive Assessment) and depression markers (Hospital Anxiety and Depression Scale). Methods: This randomized controlled trial started with 52 participants (33 men and 19 women, mean age: 69.2 ± 10.7) divided into three groups: HIIT + MICT combined, MICT, and control. Both exercise groups consisted of 4 weekly sessions including supervised and at-home exercise. Outcomes were assessed at T0 (baseline measure), T6 (end of exercise protocols), and T12 (follow-up), 40 participants having completed the 12-month follow-up. Results: At T6, both HIIT+MICT and MICT programs provided a similar increase of CRF (3 ml·min-1·kg-1) from baseline ( Conclusion: A 6-month HIIT + MICT combined program and a standard MICT program induced similar improvements in CRF, self-reported physical activity and anxiety and depression markers among patients with prior ischemic stroke or TIA compared with a control group. These effects appear to persist over time. Addition of HIIT was safe and considered acceptable by participants. Our results do not support any superiority of the combination HIIT + MICT nor disadvantage vs. MICT in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.