ArticleFrontiers in endocrinology2022
Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pregnancy and perinatal outcomes after day 5 versus day 6 blastocyst-stage embryo transfer: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Association between duration of progesterone supplementation and clinical outcomes in artificial frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2023Trial
- Inner Cell Mass Grade and Earlier Blastulation Are Associated with Pregnancy Outcomes in Euploid Embryos.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Evaluation of day 5 versus day 6 blastocyst biopsy in preimplantation genetic testing: clinical and neonatal outcomes.Frontiers in endocrinology · 2025Article
- Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes.Frontiers in endocrinology · 2025Article
- Multi-omics PGT: re-evaluation of euploid blastocysts for implantation potential based on RNA sequencing.Human reproduction (Oxford, England) · 2024Article
- Trophectoderm, Inner Cell Mass, and Expansion Status for Live Birth Prediction After Frozen Blastocyst Transfer: The Winner Is Trophectoderm.Life (Basel, Switzerland) · 2024Article
- Time-lapse imaging of morula compaction for selecting high-quality blastocysts: a retrospective cohort study.Archives of gynecology and obstetrics · 2024Article
- Effect of repeated vitrification of human embryos on pregnancy and neonatal outcomes.Journal of ovarian research · 2024Article
- Reply: Double vitrification and warming do not compromise the chance of live birth-a potential invalid conclusion.Human reproduction open · 2024Article
- PGT-A improved singleton live birth rate among all age groups of women who underwent elective single blastocyst transfer: a single-centre retrospective study.Journal of assisted reproduction and genetics · 2023Article
- Effect of development speed and quality of blastocyst on singleton birthweight in single frozen-thawed blastocyst transfer cycles.Frontiers in endocrinology · 2023Article
- Development and validation of a nomogram for predicting ongoing pregnancy in single vitrified-warmed blastocyst embryo transfer cycles.Frontiers in endocrinology · 2023Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Day 5 (D5) blastocysts are generally given priority to transfer than day 6 (D6) blastocysts; however, which one should be prioritized to transfer when only low-grade D5 and high-grade D6 blastocysts are available? Methods: A large retrospective cohort study was carried out to evaluate the live birth rate (LBR) following D5 and D6 blastocysts in single frozen-thawed blastocyst transfer (FBT) during January 2014 and December 2018. A multivariate logistic regression was conducted to evaluate the combined impact of expansion day (D5 and D6) and blastocyst quality (high grade/low grade) on LBR, accounting for the potential confounding factors. The biopsied blastocysts from a consecutive PGT-A case series during February 2013 to December 2021 were analyzed in a supplementary study. Results: The LBR achieved in high-grade D6 blastocyst transfer was significantly higher than that in low-grade D5 blastocyst transfer (50.43% vs. 40.70%, aOR 1.54, 95% CI 1.05-2.26, Conclusions: Our data suggest that D6 blastocysts with high morphology grading are preferred than D5 blastocysts with low morphology grading when selecting blastocyst transfer to shorten the time of conception.
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