ArticlePhotoacoustics2023
High-fidelity deep functional photoacoustic tomography enhanced by virtual point sources.
Article in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 20 citations in OpenAlex.
- Robust automated three-dimensional speed-of-sound compensation for hemispherical photoacoustic computed tomography.Photoacoustics · 2026Article
- Activatable smart contrast agents for photoacoustic imaging.Smart molecules : open access · 2026Review
- 3D-PAULM: Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy for Multiparametric Brain and Tumor Imaging.bioRxiv : the preprint server for biology · 2026Article
- Volumetric photoacoustic/ultrasound image fusion and enhancement with dual-tree complex wavelet transform.Biomedical optics express · 2026Article
- Ultrasound-guided sound speed correction for photoacoustic computed tomography.Photoacoustics · 2026Article
- From light to sound: Seeing and hearing the placenta in health and disease.Science advances · 2026Review
- A Hybrid Diffusion Model Enhances Multiparametric 3D Photoacoustic Computed Tomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Volumetric ultrasound and photoacoustic imaging of inflammatory arthritis in human finger joints via robotic arm powered arc scans.Biomedical optics express · 2025Article
- Non-Invasive Deep-Brain Imaging With 3D Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy (3D-PAULM).IEEE transactions on medical imaging · 2025Article
- Nanoporous Submicron Gold Particles Enable Nanoparticle-Based Localization Optoacoustic Tomography (nanoLOT).Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Photoacoustic Tomography with Temporal Encoding Reconstruction (PATTERN) for cross-modal individual analysis of the whole brain.Nature communications · 2024Article
- On the Importance of Low-Frequency Signals in Functional and Molecular Photoacoustic Computed Tomography.IEEE transactions on medical imaging · 2024Article
- Deep tissue photoacoustic imaging with light and sound.Npj imaging · 2024Review
- Review of Deep Learning Approaches for Interleaved Photoacoustic and Ultrasound (PAUS) Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Article
- On the importance of low-frequency signals in functional and molecular photoacoustic computed tomography.ArXiv · 2023Article
- Multiscale photoacoustic tomography using reversibly switchable thermochromics.Journal of biomedical optics · 2023Article
- Article
- Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke.Journal of visualized experiments : JoVE · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Photoacoustic tomography (PAT), a hybrid imaging modality that acoustically detects the optical absorption contrast, is a promising technology for imaging hemodynamic functions in deep tissues far beyond the traditional optical microscopy. However, the most clinically compatible PAT often suffers from the poor image fidelity, mostly due to the limited detection view of the linear ultrasound transducer array. PAT can be improved by employing highly-absorbing contrast agents such as droplets and nanoparticles, which, however, have low clinical translation potential due to safety concerns and regulatory hurdles imposed by these agents. In this work, we have developed a new methodology that can fundamentally improve PAT's image fidelity without hampering any of its functional capability or clinical translation potential. By using clinically-approved microbubbles as virtual point sources that strongly and isotropically scatter the local pressure waves generated by surrounding hemoglobin, we can overcome the limited-detection-view problem and achieve high-fidelity functional PAT in deep tissues, a technology referred to as virtual-point-source PAT (VPS-PAT). We have thoroughly investigated the working principle of VPS-PAT by numerical simulations and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.