Evidence map›Paper›PMID 36685725›Full record

ArticleNAR genomics and bioinformatics2023

Model-driven experimental design workflow expands understanding of regulatory role of Nac in

Joon Young Park, Sang-Mok Lee, Ali Ebrahim, Zoe K Scott-Nevros, Jaehyung Kim, Laurence Yang, Anand Sastry, Sang Woo Seo, Bernhard O Palsson, Donghyuk Kim

Open access · goldAbstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. A systems-level atlas of carbon-response transcriptional states inProceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Joon Young ParkSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.ORCID https://orcid.org/0000-0002-2059-2387
Sang-Mok LeeSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
Ali EbrahimDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Zoe K Scott-NevrosSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
Jaehyung KimSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.ORCID https://orcid.org/0000-0003-2357-6785
Laurence YangDepartment of Chemical Engineering, Queen's University, Kingston, Canada.
Anand SastryDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0002-8293-3909
Sang Woo SeoSchool of Chemical and Biological Engineering, and Interdisciplinary Program in Bioengineering, and Institute of Chemical Processes, and Bio-MAX Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.ORCID https://orcid.org/0000-0002-7434-7053
Bernhard O PalssonDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Donghyuk KimSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.ORCID https://orcid.org/0000-0001-6489-032X
Ulsan National Institute of Science and Technology · KRUniversity of California San Diego · USNovo Nordisk Foundation · DKQueen's University · CASeoul National University · KR

Funding

GENOMICALLY BASED MODELS FOR ANTIBIOTIC DEVELOPMENTR01GM057089 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 1998 to 2021
$6.9M
Multiscale Molecular Systems Biology: Reconstruction and Model OptimizationU01GM102098 · NIGMS · STANFORD UNIVERSITY · PI SAUNDERS, MICHAEL ALAN · 2012 to 2016
$1.8M
NIGMS NIH HHS R01 GM057089NIGMS NIH HHS U01 GM102098
6 · The paper itself

Abstract

The establishment of experimental conditions for transcriptional regulator network (TRN) reconstruction in bacteria continues to be impeded by the limited knowledge of activating conditions for transcription factors (TFs). Here, we present a novel genome-scale model-driven workflow for designing experimental conditions, which optimally activate specific TFs. Our model-driven workflow was applied to elucidate transcriptional regulation under nitrogen limitation by Nac and NtrC, in

Identifiers

PMID36685725
PMCPMC9853098
OpenAlexW4317624614

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.