Evidence map›Paper›PMID 36685637›Full record

ReviewNano research2023

Use of stimulatory responsive soft nanoparticles for intracellular drug delivery.

Krystal A Hughes, Bishal Misra, Maryam Maghareh, Sharan Bobbala

Abstract readReview
In one paragraph

Review in Nano research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
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  6. Review
  7. Article
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  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Krystal A HughesDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505 USA.
Bishal MisraDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505 USA.
Maryam MagharehDepartment of Clinical Pharmacy, West Virginia University School of Pharmacy, Morgantown, WV 26505 USA.
Sharan BobbalaDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug delivery has made tremendous advances in the last decade. Targeted therapies are increasingly common, with intracellular delivery highly impactful and sought after. Intracellular drug delivery systems have limitations due to imprecise and non-targeted release profiles. One way this can be addressed is through using stimuli-responsive soft nanoparticles, which contain materials with an organic backbone such as lipids and polymers. The choice of biomaterial is essential for soft nanoparticles to be responsive to internal or external stimuli. The nanoparticle must retain its integrity and payload in non-targeted physiological conditions while responding to particular intracellular environments where payload release is desired. Multiple internal and external factors could stimulate the intracellular release of drugs from nanoparticles. Internal stimuli include pH, oxidation, and enzymes, while external stimuli include ultrasound, light, electricity, and magnetic fields. Stimulatory responsive soft nanoparticulate systems specifically utilized to modulate intracellular delivery of drugs are explored in this review.

Indexed as

biomaterialsintracellular drug deliverynanoparticlesstimuli-responsivetargeted delivery

Identifiers

PMID36685637
PMCPMC9840428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.