Evidence map›Paper›PMID 36685601›Full record

ArticleFrontiers in immunology2022

Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination.

Takuto Nogimori, Koichiro Suzuki, Yuji Masuta, Ayaka Washizaki, Mika Yagoto, Mami Ikeda, Yuki Katayama, Hidenori Kanda, Minoru Takada, Shohei Minami and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Renaissance of antiviral CD8Nature reviews. Immunology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Optimizing CD8Experimental hematology & oncology · 2024
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Takuto NogimoriLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Koichiro SuzukiThe Research Foundation for Microbial Diseases of Osaka University (BIKEN), Osaka, Japan.
Yuji MasutaLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Ayaka WashizakiLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Mika YagotoLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Mami IkedaLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Yuki KatayamaLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Hidenori KandaKINSHUKAI, Hanwa Memorial Hospital, Osaka, Japan.
Minoru TakadaKINSHUKAI, Hanwa The Second Senboku Hospital, Osaka, Japan.
Shohei MinamiDepartment of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Takeshi KobayashiDepartment of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Shokichi TakahamaLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Yasuo YoshiokaThe Research Foundation for Microbial Diseases of Osaka University (BIKEN), Osaka, Japan.
Takuya YamamotoLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Osaka University · JPNational Institute of Biomedical Innovation, Health and Nutrition · JPHanwa Memorial Hospital · JPJikei University Kashiwa hospital · JPKyoto Biken Laboratories (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the T-cell responses involved in inhibiting COVID-19 severity is crucial for developing new therapeutic and vaccine strategies. Here, we characterized SARS-CoV-2 spike-specific CD8

Indexed as

Antineoplastic AgentsCOVID-19BNT162 VaccineCD8-Positive T-LymphocytesHumansRNA, MessengerSARS-CoV-2VaccinationAntineoplastic AgentsBNT162 VaccineRNA, MessengerCOVID-19cytotoxic T cellsmRNA vaccineSARS-CoV-2TCR repertoire

Identifiers

PMID36685601
PMCPMC9845949
OpenAlexW4313588566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.