Observational studyFrontiers in immunology2022
Open access · goldAbstract readObservational Study
In one paragraph
Observational study in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
15.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 73 citations in OpenAlex.
- Genetic and transcriptomic determinants of disseminated coccidioidomycosis identify a founder variant inmedRxiv : the preprint server for health sciences · 2026Article
- Interferon-Inducible Gene Upregulation Correlates With Successful Viral Clearance in Patients With BK Polyomavirus-Associated Nephropathy.Kidney international reports · 2026Article
- Benign Adrenal Adenomas Are Associated With Reduced Prevalence of Hospitalised Patients With COVID-19.Clinical endocrinology · 2026Article
- Analyzing the Molecular Signature Genes and Pathways of Dengue Fever, Dengue Hemorrhagic Fever and Dengue Shock Syndrome Caused by Dengue Virus in India.Molecular biotechnology · 2026Article
- Explainable AI multiomics analysis reveals shared and divergent host responses in COVID-19 and influenza.NPJ digital medicine · 2026Article
- Transcriptome changes in circulating immune cells of critical COVID-19 patients predict a specific metabolic and epigenetic imprint.Journal of translational medicine · 2026Article
- Interferon alpha-inducible protein 27 (IFI27) inhibits hepatitis B virus (HBV) transcription through downregulating cellular transcription factor C/EBPα.Journal of virology · 2025Article
- Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections.bioRxiv : the preprint server for biology · 2025Article
- Deep generative modeling of sample-level heterogeneity in single-cell genomics.Nature methods · 2025Article
- Single-cell sequencing reveals distinct peripheral immune responses in anti-MDA5 antibody positive dermatomyositis with rapidly progressive interstitial lung disease.Arthritis research & therapy · 2025Article
- Molecular landscape of respiratory infection: A large-scale, multi-centre blood transcriptome dataset.Scientific data · 2025Article
- Profiling short-term longitudinal severity progression and associated genes in COVID-19 patients using EHR and single-cell analysis.Scientific reports · 2025Article
- Evaluating the InSignia IFI27 expression assay for detecting viral respiratory infection compared to a traditional gene normalisation assay.Scientific reports · 2025Article
- Integrated multi-sample transcriptomic analysis of COVID-19 patients against controls using a bioinformatics pipeline.Scientific reports · 2025Article
- IFN alpha inducible protein 27 (IFI27) acts as a positive regulator of PACT-dependent PKR activation after RNA virus infections.PLoS pathogens · 2025Article
- Genetic and Inflammatory Signatures Associated With Worse Prognosis in Hospitalized Patients With Severe SARS-CoV-2 Infection With and Without Diabetes.Journal of medical virology · 2025Article
- Host transcriptome response to Mycoplasma bovis and bovine viral diarrhea virus in bovine tissues.BMC genomics · 2025Article
- Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers.Journal of translational medicine · 2025Article
- Transcriptomic Biomarkers Associated With Microbiological Etiology and Disease Severity in Childhood Pneumonia.The Journal of infectious diseases · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
60 authors at 19 institutions in 8 countries.
Maryam ShojaeiDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Amir ShamshirianGastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
James MonkmanFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Laura GriceInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Minh TranInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Chin Wee TanThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia.
Siok Min TeoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Gustavo Rodrigues RossiFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Timothy R McCullochFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Marek NalosDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Maedeh RaeiGastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Alireza RazaviStudent Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Roya GhasemianAntimicrobial Resistance Research Centre, Department of Infectious Diseases, Mazandaran University of Medical Sciences, Sari, Iran.
Mobina GheibiStudent Research Committee, School of Allied Medical Sciences, Mazandaran University of Medical Science, Sari, Iran.
Fatemeh RoozbehMazandaran University of Medical Sciences, Sari, Iran.
Peter D SlyChild Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia.
Kirsten M SpannCentre for Immunology and Infection Control, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Keng Yih ChewSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Yanshan ZhuSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Yao XiaSchool of Science, Edith Cowan University; School of Biomedical Science, University of Western Australia, Perth, WA, Australia.
Timothy J WellsFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Alexandra Cristina SenegagliaComplexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil.
Carmen Lúcia KuniyoshiComplexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil.
Claudio Luciano FranckComplexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil.
Anna Flavia Ribeiro Dos SantosPontifical Catholic University of Parana, Curitiba, Brazil.
Lucia de NoronhaPontifical Catholic University of Parana, Curitiba, Brazil.
Sepideh MotamenDepartment of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Reza ValadanMolecular and Cell Biology Research Centre, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Omolbanin AmjadiGastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Rajan GognaBiotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Esha MadanCampania Centre for the Unknown, Lisbon, Portugal.
Reza Alizadeh-NavaeiGastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Liliana LampertiDepartment of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile.
Felipe ZuñigaMolecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile.
Estefania Nova-LampertiMolecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile.
Gonzalo LabarcaDepartment of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile.
Ben KnippenbergInfectious Diseases Department, Royal Darwin Hospital, Darwin, NT, Australia.
Velma HerwantoFaculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia.
Ya WangDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Amy PhuDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Tracy ChewSydney Informatics Hub, Core Research Facilities, University of Sydney, Sydney, NSW, Australia.
Timothy KwanDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Karan KimCentre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia.
Sally TeohDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Tiana M PelaiaDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Win Sen KuanEmergency Medicine Department, National University Hospital, National University Health System, Singapore, Singapore.
Yvette JeeEmergency Medicine Department, National University Hospital, National University Health System, Singapore, Singapore.
Jon IredellFaculty of Medicine and Health, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.
Ken O'ByrneQueensland University of Technology, Centre for Genomics and PersonalisedHealth, School of Biomedical Sciences, Brisbane, QLD, Australia.
John F FraserCritical Care Research Group, The University of Queensland, Brisbane, QLD, Australia.
Melissa J DavisThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia.
Gabrielle T BelzFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Majid E WarkianiAustralia Centre for Health Technologies (CHT) & Institute for Biomedical Materials & Devices (IBMD), School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia.
Carlos Salomon GalloDepartment of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile.
Fernando Souza-Fonseca-GuimaraesFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Quan NguyenInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Anthony McleanDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Arutha KulasingheFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Kirsty R ShortSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Benjamin TangDepartment of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
The University of Queensland · AUMazandaran University of Medical Sciences · IRNepean Hospital · AUUniversity of Concepción · CLWestmead Institute for Medical Research · AUPontifícia Universidade Católica do Paraná · BRHospital de Clínicas Universidade Federal do Paraná · BRQueensland University of Technology · AUWalter and Eliza Hall Institute of Medical Research · AUCentre for Research in Anthropology · PTEdith Cowan University · AUNational University Health System · SGNational University Hospital · SGRoyal Darwin Hospital · AUTarbiat Modares University · IRTarumanagara University · IDThe University of Sydney · AUUniversity of Copenhagen · DKUniversity of Technology Sydney · AU
Funding
Medical Research Council 1135898Medical Research Council 1140406Medical Research Council 1157741Medical Research Council 1195451Medical Research Council 2007919
Abstract
Purpose: Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate biomarkers have been proposed for COVID-19. However, at present, there is no consensus on the best diagnostic approach to predict outcomes in infected patients. Moreover, it is not clear whether such tools would apply to other potentially pandemic pathogens and therefore of use as stockpile for future pandemic preparedness. Methods: We conducted a multi-cohort observational study to investigate the biology and the prognostic role of interferon alpha-inducible protein 27 ( Results: We show that Conclusion: These data suggest that prognostic biomarkers targeting the family of
Indexed as
COVID-19Influenza A Virus, H1N1 SubtypeInfluenza, HumanBiomarkersHumansMembrane ProteinsSARS-CoV-2BiomarkersIFI27 protein, humanMembrane ProteinsbiomarkersCOVID-19early predictorIFI27SARS-CoV-2
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.