Evidence map›Paper›PMID 36685588›Full record

ReviewFrontiers in immunology2022

The role of

Mengyu Zheng, Ran Han, Yali Yuan, Yunqi Xing, Wenji Zhang, Zhongmei Sun, Yuyue Liu, Junxiang Li, Tangyou Mao

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 3 pooled it
29.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 3 syntheses or guidelines pooled it, 193 citations in OpenAlex.

  1. Pooled it
  2. The role ofFrontiers in medicine · 2025
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Arctic Fox-DerivedLife (Basel, Switzerland) · 2026
    Article
  16. Article
  17. From copper imbalance to immunometabolic remodeling: cuproptosis-related vulnerability and therapeutic hypotheses in autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  18. Article
  19. Article
  20. Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mengyu ZhengUniversity of Bristol, Bristol, United Kingdom.
Ran HanDongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Yali YuanDongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Yunqi XingDongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Wenji ZhangDongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Zhongmei SunTianjin Nankai Hospital, Tianjin, China.
Yuyue LiuDongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Junxiang LiDongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Tangyou MaoDongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Beijing University of Chinese Medicine · CNTianjin Nankai Hospital · CNUniversity of Bristol · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, is a chronic relapsing gastrointestinal inflammatory disease mediated by dysregulated immune responses to resident intestinal microbiota. Current conventional approaches including aminosalicylates, corticosteroids, immunosuppressive agents, and biological therapies are focused on reducing intestinal inflammation besides inducing and maintaining disease remission, and managing complications. However, these therapies are not curative and are associated with various limitations, such as drug resistance, low responsiveness and adverse events. Recent accumulated evidence has revealed the involvement of mucin-degrading bacterium

Indexed as

Inflammatory Bowel DiseasesProbioticsAkkermansiaChronic DiseaseHumansVerrucomicrobiaAkkermansia muciniphilabarrier functiongut microbiotainflammatory bowel diseasemucosal immunity

Identifiers

PMID36685588
PMCPMC9853388
OpenAlexW4313641460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.