Evidence map›Paper›PMID 36685586›Full record

ArticleFrontiers in immunology2022

A case report of steroid-refractory bullous pemphigoid induced by immune checkpoint inhibitor therapy.

Shasha Guan, Linlin Zhang, Junyan Zhang, Wenjing Song, Diansheng Zhong

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shasha GuanDepartment of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China.
Linlin ZhangDepartment of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China.
Junyan ZhangDepartment of Dermatology, Tianjin Medical University General Hospital, Tianjin, China.
Wenjing SongDepartment of Pathology, Tianjin Medical University, Tianjin, China.
Diansheng ZhongDepartment of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China.
Tianjin Medical University General Hospital · CNTianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The widespread use of immune checkpoint inhibitors in several malignancies has revealed new immune-related adverse events. Bullous pemphigoid (BP) is an antibody-driven autoimmune disease characterized by skin inflammation and fluid-filled bullae. Herein, a 69-year-old man with lung squamous cell carcinoma developed multiple vesicles and tense bullae 3 weeks after the initiation of a programmed death-1 (PD-1) inhibitor, pembrolizumab, and chemotherapy. Biopsy revealed a subepidermal bulla with lymphocytic and eosinophil infiltration, and immunohistochemical studies predominantly showed CD4

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsPemphigoid, BullousAgedBlisterHumansImmune Checkpoint InhibitorsMaleSteroidsImmune Checkpoint InhibitorsSteroidsbullous pemphigoidimmune checkpoint inhibitorintravenous immunoglobulinlung carcinomapembrolizumab

Identifiers

PMID36685586
PMCPMC9845947
OpenAlexW4313585141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.