Evidence map›Paper›PMID 36685543›Full record

ReviewFrontiers in immunology2022

Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis.

Shuo Yang, Long Wang, Yuesong Wu, Anguo Wu, Feihong Huang, Xiaoqin Tang, Fahsai Kantawong, Songyot Anuchapreeda, Dalian Qin, Qibing Mei and 4 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Shuo YangSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Long WangSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Yuesong WuSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Anguo WuSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Feihong HuangSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Xiaoqin TangSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Fahsai KantawongDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Songyot AnuchapreedaDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Dalian QinSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Qibing MeiSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Jianping ChenSchool of Chinese Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Xinwu HuangSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Chunxiang ZhangInstitute of Cardiovascular Research, the Key Laboratory of Medical Electrophysiology, Ministry of Education of China, Medical Key Laboratory for Drug Discovery and Druggability Evaluation of Sichuan Province, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Luzhou, China.
Jianming WuSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Southwest Medical University · CNChiang Mai University · THChinese University of Hong Kong · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelets, generated from precursor megakaryocytes (MKs), are central mediators of hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated by multiple factors, and related to many cellular events including apoptosis. However, the role of apoptosis in thrombopoiesis has been controversial for many years. Some researchers believe that apoptosis is an ally of thrombopoiesis and platelets production is apoptosis-dependent, while others have suggested that apoptosis is dispensable for thrombopoiesis, and is even inhibited during this process. In this review, we will focus on this conflict, discuss the relationship between megakaryocytopoiesis, thrombopoiesis and apoptosis. In addition, we also consider why such a vast number of studies draw opposite conclusions of the role of apoptosis in thrombopoiesis, and try to figure out the truth behind the mystery. This review provides more comprehensive insights into the relationship between megakaryocytopoiesis, thrombopoiesis, and apoptosis and finds some clues for the possible pathological mechanisms of platelet disorders caused by abnormal apoptosis.

Indexed as

MegakaryocytesThrombopoiesisApoptosisBlood PlateletsFenbendazoleHemostasisFenbendazoleapoptosisapoptosis-related moleculesautophagymegakaryocytopoiesisthrombopoiesis

Identifiers

PMID36685543
PMCPMC9845629
OpenAlexW4313585900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.