ArticleFrontiers in molecular biosciences2022
Challenges in predicting stabilizing variations: An exploration.
Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Rational Design ofBiotech (Basel (Switzerland)) · 2026Article
- Recessive variants in mitochondrial complex I nuclear subunits are an underrated cause of optic atrophy.Brain : a journal of neurology · 2026Article
- MuFaDDG: a sequence-based multiscale feature fusion framework for protein stability changes prediction.Bioinformatics (Oxford, England) · 2026Article
- JanusDDG: a physics-informed neural network for sequence-based protein stability via two-fronts attention.Communications biology · 2026Article
- Generalizable and scalable protein stability prediction with rewired protein generative models.Nature communications · 2025Article
- Enriching stabilizing mutations through automated analysis of molecular dynamics simulations using BoostMut.Protein science : a publication of the Protein Society · 2025Article
- Mass balance approximation of unfolding boosts potential-based protein stability predictions.Protein science : a publication of the Protein Society · 2025Article
- Widespread adaptive evolution in angiosperm photosystems provides insight into the evolution of photosystem II repair.The Plant cell · 2024Article
- Expert-guided protein language models enable accurate and blazingly fast fitness prediction.Bioinformatics (Oxford, England) · 2024Article
- The origin of mutational epistasis.European biophysics journal : EBJ · 2024Article
- Analysis of proteins in the light of mutations.European biophysics journal : EBJ · 2024Review
- Stability Oracle: a structure-based graph-transformer framework for identifying stabilizing mutations.Nature communications · 2024Article
- Assessing computational tools for predicting protein stability changes upon missense mutations using a new dataset.Protein science : a publication of the Protein Society · 2024Article
- Predicting the Effect of Single Mutations on Protein Stability and Binding with Respect to Types of Mutations.International journal of molecular sciences · 2023Article
- Empirical validation of ProteinMPNN's efficiency in enhancing protein fitness.Frontiers in genetics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An open challenge of computational and experimental biology is understanding the impact of non-synonymous DNA variations on protein function and, subsequently, human health. The effects of these variants on protein stability can be measured as the difference in the free energy of unfolding (ΔΔ
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.