Evidence map›Paper›PMID 36685271›Full record

ArticleToxicology reports2023

Effects of Au@Ag core-shell nanostructure with alginate coating on male reproductive system in mice.

Mahsa Nazari, Ronak Shabani, Marziyeh Ajdary, Mohsen Ashjari, Reza Shirazi, Azam Govahi, Fatemeh Kermanian, Mehdi Mehdizadeh

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Mahsa NazariDepartment of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ronak ShabaniReproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.
Marziyeh AjdaryEndometriosis Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Mohsen AshjariChemical Engineering Department, Faculty of Engineering, University of Kashan, Kashan, Iran.
Reza ShiraziDepartment of Anatomy, School of Medical Sciences, Medicine & Health, UNSW Sydney, Sydney, Australia.
Azam GovahiEndometriosis Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Fatemeh KermanianDepartment of Anatomy, Alborz University of Medical Sciences, Karaj, Iran.
Mehdi MehdizadehReproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRAlborz University of Medical SciencesUniversity of Kashan · IRUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the widespread use of silver nanoparticles (NPs), these NPs can accumulate and have toxic effects on various organs. However, the effects of silver nanostructures (Ag-NS) with alginate coating on the male reproductive system have not been studied. Therefore, this study aimed to investigate the impacts of this NS on sperm function and testicular structure. After the synthesis and characterization of Ag-NS, the animals were divided into five groups (n = 8), including one control group, two sham groups (received 1.5 mg/kg/day alginate solution for 14 and 35 days), and two treatment groups (received Ag-NS at the same dose and time). Following injections, sperm parameters, apoptosis, and autophagy were analyzed by the TUNEL assay and measurement of the mRNA expression of

Indexed as

AA, Ascorbic acidAgNO3,, Silver nitrateAg-NPs, silver nanoparticlesAMPkinase, 5' adenosine monophosphate-activated protein kinaseANOVA, Analysis of varianceApoptosisAtg3, Autophagy related 3AutophagyBAX, Bcl-2-associated X proteinBcl-2, B-cell lymphoma 2BTB, Blood-testes barriercDNA, Complementary DNACSNs, Core-shell nanostructuresCTAB, Cetyltrimethylammonium bromidect, cycle thresholdDLS, Dynamic light scatteringdUTP, Deoxyuridine triphosphateDW, Distilled waterFertilizationFTIR, Fourier transform infrared spectroscopyFYN kinase, Proto-oncogene tyrosine-protein kinaseH2SO4,, Sulphuric acidHAuCl4, Tetrachloroauric acid trihydratehCG, human chorionic gonadotropinHR-TEM, High-resolution transmission electron microscopyICP-MS, Inductively coupled plasma mass spectrometryIgE, Immunoglobulin EIL, InterleukinsIU, International UnitNaBH4,, Sodium borohydrideNanostructuresNaOH, Sodium hydroxideNIH, National Institutes of HealthNMRI, Naval Medical Research InstituteNMs, NanomaterialsNRs, Nano rodsOD, Optical densityPBS, Phosphate-buffered salinePdI, Polydispersity indexPI, Propidium IodidePMSG, Pregnant Mare Serum Gonadotropinq RT-PCR, Quantitative real time - polymerase chain reactionROS, Reactive oxygen speciesrpm, Rotations Per MinuteSD, standard deviationSemen analysisSERS, Surface enhanced Raman scatteringSNRs, Silver Nano rodsSSCs, Spermatogonial stem cellsTDT, Terminal deoxynucleotidyl transferaseTesticular tissueTGA, Thermal gravimetric AnalysisTGF-β, Transforming growth factorTUNEL, Terminal deoxynucleotidyl transferase dUTP nick end labeling

Identifiers

PMID36685271
PMCPMC9853145
OpenAlexW4313897893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.