Stereoselective [2+2]-Cycloadditions of chiral allenic ketones and alkenes: Applications towards the synthesis of benzocyclobutenes and endiandric acids.

Renyu Guo, Brittany P Witherspoon, M Kevin Brown

Abstract read

In one paragraph

Article in Tetrahedron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Lewis Acid-Promoted [2 + 2] Cycloadditions of Allenes and Ketenes: Versatile Methods for Natural Product Synthesis.Accounts of chemical research · 2023
Article

4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Renyu GuoIndiana University, Department of Chemistry, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.

Brittany P WitherspoonIndiana University, Department of Chemistry, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.

M Kevin BrownIndiana University, Department of Chemistry, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.

Funding

Methods and Strategies for Chemical SynthesisR35GM131755 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael Kevin Brown · 2019 to 2026

$4.0M

NIGMS NIH HHS R35 GM131755

6 · The paper itself

Abstract

Cyclobutanes are important motifs that have found utility in many contexts. Prior work has demonstrated an enantioselective isomerization/stereoselective [2 + 2] as a means to access bicyclo [4.2.0] octanes. Herein, the utility of this method is demonstrated towards the synthesis of benzocyclobutenes and a key intermediate towards the endiandric acids.

Indexed as

AllenesCycloadditionCyclobutaneEnantioselectiveLewis-acid

Identifiers

PMID36685046

DOI10.1016/j.tet.2022.132932

PMCPMC9850822

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