Evidence map›Paper›PMID 36684672›Full record

ArticlePeerJ2023

High and low dose of luzindole or 4-phenyl-2-propionamidotetralin (4-P-PDOT) reverse bovine granulosa cell response to melatonin.

Wenju Liu, Zhihao Chen, Rui Li, Menghao Zheng, Xunsheng Pang, Aiyou Wen, Bing Yang, Shujuan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Multi-Omics Analysis of the Effects ofInternational journal of molecular sciences · 2026
    Article
  2. Melatonin in Male Dromedary Camel (Animals : an open access journal from MDPI · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wenju LiuCollege of Life and Health Science, Anhui Science and Technology University, Fengyang, China.
Zhihao ChenCollege of Animal Science, Anhui Science and Technology University, Fengyang, China.
Rui LiCollege of Animal Science, Anhui Science and Technology University, Fengyang, China.
Menghao ZhengCollege of Animal Science, Anhui Science and Technology University, Fengyang, China.
Xunsheng PangCollege of Animal Science, Anhui Science and Technology University, Fengyang, China.
Aiyou WenCollege of Animal Science, Anhui Science and Technology University, Fengyang, China.
Bing YangCollege of Animal Science, Anhui Science and Technology University, Fengyang, China.
Shujuan WangCollege of Animal Science, Anhui Science and Technology University, Fengyang, China.
Anhui Science and Technology University · CNAnhui University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Communication between oocytes and granulosa cells ultimately dictate follicle development or atresia. Melatonin is also involved in follicle development. This study aimed to investigate the effects of melatonin and its receptor antagonists on hormone secretion, as well as gene expression related to hormone synthesis, TGF- Methods: Bovine ovaries were collected from a local abattoir and follicular fluid (follicle diameter 5-8 mm) was collected for granulosa cell isolation and culture. Granulosa cells and culture medium were collected 48 h after treatment with melatonin at high dose concentrations (10 Results: Both 10 Conclusion: High and low dose melatonin receptor antagonists exhibited different effects in regulating hormone secretion and the expression of various genes in response to melatonin. Therefore, concentration effects must be considered when using luzindole or 4-P-PDOT.

Indexed as

Granulosa CellsMelatoninAnimalsCattleCholesterol Side-Chain Cleavage EnzymeCore Binding Factor Alpha 1 SubunitErbB ReceptorsEstradiolFemaleProgesteroneTryptaminesCholesterol Side-Chain Cleavage EnzymeCore Binding Factor Alpha 1 SubunitErbB ReceptorsEstradiolluzindoleMelatoninProgesteroneTryptamines4-P-PDOTBovineGene regulationGranulosa cellHormonal synthesisLuzindoleMelatonin

Identifiers

PMID36684672
PMCPMC9851050
OpenAlexW4316465810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.