ArticleFrontiers in cardiovascular medicine2022
Causal association of peripheral immune cell counts and atrial fibrillation: A Mendelian randomization study.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Association of Prognostic Nutritional Index and New-Onset Atrial Fibrillation in Patients Undergoing Surgical Aortic Valve Replacement: A Silent Predictor in Perioperative Outcomes?Journal of clinical medicine · 2026Article
- Analysis of the Correlation Between Helper T-Lymphocyte Subsets and Atrial Fibrillation: An Observational and Mendelian Randomization Study.Cardiovascular therapeutics · 2026Observational
- C-reactive protein-albumin-lymphocyte index and atrial fibrillation recurrence after radiofrequency ablation in heart failure.iScience · 2025Article
- From Tissue to Transcriptome: A Systematic Review of Multi-Level Evidence for Immune Dysregulation in Atrial Fibrillation.Journal of clinical medicine · 2025Review
- The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities.Life (Basel, Switzerland) · 2025Article
- Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis.Hereditas · 2025Article
- Integrated bioinformatic analysis reveals the underlying mitochondria-associated endoplasmic reticulum membranes-related biomarkers for atrial fibrillation.Frontiers in physiology · 2025Article
- Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study.BMC oral health · 2024Article
- Association between lipid-lowering drugs and allergic diseases: A Mendelian randomization study.The World Allergy Organization journal · 2024Article
- Association between inflammation markers and all-cause mortality in critical ill patients with atrial fibrillation: Analysis of the Multi-Parameter Intelligent Monitoring in Intensive Care (MIMIC-IV) database.International journal of cardiology. Heart & vasculature · 2024Article
- The genetic relationships between immune cell traits, circulating inflammatory proteins and preeclampsia/eclampsia.Frontiers in immunology · 2024Article
- Causal relationship between human blood metabolites and risk of ischemic stroke: a Mendelian randomization study.Frontiers in genetics · 2024Article
- A mendelian randomization study investigates the causal relationship between immune cell phenotypes and cerebral aneurysm.Frontiers in genetics · 2024Article
- Causal association between immune cells and lung cancer risk: a two-sample bidirectional Mendelian randomization analysis.Frontiers in immunology · 2024Article
- The causal relationship between human blood metabolites and risk of peripheral artery disease: a Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- Prognostic Value of Four Objective Nutritional Indices in Predicting Long-Term Prognosis in Elderly Patients with Atrial Fibrillation: A Retrospective Cohort Study.Clinical interventions in aging · 2024Article
- TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.Journal of translational medicine · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Atrial fibrillation (AF) is the most common and persistent form of arrhythmia. Recently, increasing evidence has shown a link between immune responses and atrial fibrillation. However, whether the immune response is a cause or consequence of AF remains unknown. We aimed to determine whether genetically predicted peripheral immunity might have a causal effect on AF. Methods: First, we performed Mendelian randomization (MR) analyses using genetic variants strongly associated with neutrophil, eosinophil, basophil, lymphocyte, and monocyte cell counts as instrumental variables (IVs). Lymphocyte counts were then subjected to further subgroup analysis. The effect of immune cell counts on AF risk was measured using summary statistics from genome-wide association studies (GWAS). Results: Two-sample MR analysis revealed that a higher neutrophil count, basophil count and lymphocyte count had a causal effect on AF [Odds ratio (OR), 1.06, 95% confidence interval (CI), 1.01-1.10, Conclusion: Our MR analysis provided evidence of a genetically predicted causal relationship between higher peripheral immune cell counts and AF. Subgroup analysis revealed the key role of peripheral lymphocytes in AF, especially the causal relationship between CD4 + T cell count and AF. These findings are beneficial for future exploration of the mechanism of AF.
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