Evidence map›Paper›PMID 36684560›Full record

ArticleFrontiers in cardiovascular medicine2022

Single-cell transcriptomes and T cell receptors of vaccine-expanded apolipoprotein B-specific T cells.

Felix Sebastian Nettersheim, Yanal Ghosheh, Holger Winkels, Kouji Kobiyama, Christopher Durant, Sujit Silas Armstrong, Simon Brunel, Payel Roy, Thamotharampillai Dileepan, Marc K Jenkins and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. ApoB-specific CD4Frontiers in immunology · 2026
    Review
  3. Identifying sex-linked metabolomic biomarkers in fish gonads after bacterial infection.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  4. PD-1 and CD73 on naive CD4Nature immunology · 2025
    Article
  5. Review
  6. Article
  7. Atherosclerosis antigens as targets for immunotherapy.Nature cardiovascular research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Felix Sebastian NettersheimLa Jolla Institute for Immunology, La Jolla, CA, United States.
Yanal GhoshehLa Jolla Institute for Immunology, La Jolla, CA, United States.
Holger WinkelsLa Jolla Institute for Immunology, La Jolla, CA, United States.
Kouji KobiyamaLa Jolla Institute for Immunology, La Jolla, CA, United States.
Christopher DurantLa Jolla Institute for Immunology, La Jolla, CA, United States.
Sujit Silas ArmstrongLa Jolla Institute for Immunology, La Jolla, CA, United States.
Simon BrunelLa Jolla Institute for Immunology, La Jolla, CA, United States.
Payel RoyLa Jolla Institute for Immunology, La Jolla, CA, United States.
Thamotharampillai DileepanDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, United States.
Marc K JenkinsDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, United States.
Dirk M ZajoncLa Jolla Institute for Immunology, La Jolla, CA, United States.
Klaus LeyLa Jolla Institute for Immunology, La Jolla, CA, United States.
La Jolla Institute for Immunology · USUniversity of Minnesota Medical Center · US

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Vascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9M
NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R35 HL145241
6 · The paper itself

Abstract

Atherosclerotic cardiovascular diseases are the major cause of death worldwide. CD4 T cells responding to Apolipoprotein B (ApoB), the core protein of most lipoproteins, have been identified as critical disease modulators. In healthy individuals, ApoB-reactive (ApoB

Indexed as

ApoBatherosclerosis vaccineP6regulatory T cellssingle-cell RNA-sequencing

Identifiers

PMID36684560
PMCPMC9849899
OpenAlexW4313561450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.