Evidence map›Paper›PMID 36684556›Full record

ArticleFrontiers in cardiovascular medicine2022

Potential value of saline-induced Pd/Pa ratio in patients with coronary artery stenosis.

Hiroyuki Kiriyama, Arihiro Kiyosue, Shun Minatsuki, Takuya Kawahara, Susumu Katsushika, Tatsuya Kamon, Kazutoshi Hirose, Hiroki Shinohara, Mizuki Miura, Akihito Saito and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Hiroyuki KiriyamaDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Arihiro KiyosueDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Shun MinatsukiDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Takuya KawaharaBiostatistics Division, Clinical Research Promotion Center, The University of Tokyo Hospital, Tokyo, Japan.
Susumu KatsushikaDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Tatsuya KamonDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Kazutoshi HiroseDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Hiroki ShinoharaDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Mizuki MiuraDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Akihito SaitoDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Hironobu KikuchiDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Satoshi KoderaDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Masaru HatanoDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Jiro AndoDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Masahiro MyojoDepartment of Cardiology, Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan.
Nobuhiko ItohDepartment of Cardiology, Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan.
Keisuke YamamotoDepartment of Cardiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Hiroshi IkenouchiDepartment of Cardiology, Japanese Red Cross Medical Center, Tokyo, Japan.
Norifumi TakedaDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Issei KomuroDepartment of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.
University of Tokyo Hospital · JPJapanese Red Cross Medical Center · JPKanto Central Hospital · JPMaruyama Memorial General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fractional flow reserve (FFR) is the current gold standard for identifying myocardial ischemia in individuals with coronary artery stenosis. However, FFR is not penetrated as much worldwide due to time consumption, costs associated with adenosine, FFR-related discomfort, and complications. Resting physiological indexes may be widely accepted alternatives to FFR, while the discrepancies with FFR were found in up to 20% of lesions. The saline-induced Pd/Pa ratio (SPR) is a new simplified option for evaluating coronary stenosis. However, the clinical implication of SPR remains unclear. Objectives: In the present study, we aimed to compare the accuracies of SPR and resting full-cycle ratio (RFR) and to investigate the incremental value of SPR in clinical practice. Methods: In this multicenter prospective study, 112 coronary lesions (105 patients) were evaluated by SPR, RFR, and FFR. Results: The overall median age was 71 years, and 84.8% were men. SPR was correlated more strongly with FFR than with RFR ( Conclusion: Saline-induced Pd/Pa ratio predicted FFR more accurately than RFR. SPR could be an alternative method for evaluating coronary artery stenosis and further investigation including elucidation of the mechanism of SPR is needed (225 words).

Indexed as

epicardial coronary arteryfractional flow reservephysiological assessmentresting full-cycle ratiosaline-induced Pd/Pa ratio

Identifiers

PMID36684556
PMCPMC9853169
OpenAlexW4313641726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.