ArticleBioengineering & translational medicine2023
Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat-shock protein family.
Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- In Vitro Release of Curcumin and Resveratrol from Polymeric Systems: Films and Hydrogel.Gels (Basel, Switzerland) · 2026Article
- Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices.International journal of molecular sciences · 2026Review
- Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.Results and problems in cell differentiation · 2026Review
- Bilayer Biomimetic Scaffolds Loaded with Mesenchymal Stem Cell Secretomes Promote Diabetic Wound Healing.Gels (Basel, Switzerland) · 2025Article
- Combination Therapy with Human Chorionic Villi MSCs and Secretory Factors Enhances Cutaneous Wound Healing in a Rat Model.International journal of molecular sciences · 2025Article
- Precision exosome engineering for enhanced wound healing and scar revision.Journal of translational medicine · 2025Review
- Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation.Journal of molecular histology · 2025Review
- Effects of Hydrogels on Mesenchymal Stem/Stromal Cells Paracrine Activity and Extracellular Vesicles Production.Journal of extracellular vesicles · 2025Review
- Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation.Stem cell research & therapy · 2025Article
- The Effect of Stem Cell Secretome on the Improvement of Diabetic Wound Recovery: A Systematic Review and Meta-Analysis of In Vivo Studies.Current therapeutic research, clinical and experimental · 2025Review
- Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment.Bioactive materials · 2024Article
- Black phosphorus for bone regeneration: Mechanisms involved and influencing factors.Materials today. Bio · 2024Review
- Emerging roles of exosomes in oral diseases progression.International journal of oral science · 2024Review
- Senescence induces fundamental changes in the secretome of mesenchymal stromal cells (MSCs): implications for the therapeutic use of MSCs and their derivates.Frontiers in bioengineering and biotechnology · 2023Review
- Research progress on the mechanism of angiogenesis in wound repair and regeneration.Frontiers in physiology · 2023Review
- Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight.Frontiers in bioengineering and biotechnology · 2023Review
- Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat-shock protein family.Bioengineering & translational medicine · 2023Article
- Bioactive Scaffold Fabricated by 3D Printing for Enhancing Osteoporotic Bone Regeneration.Bioengineering (Basel, Switzerland) · 2022Article
- Cell Secretome Strategies for Controlled Drug Delivery and Wound-Healing Applications.Polymers · 2022Review
- Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?Pharmaceuticals (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
23 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high mortality rate of patients with diabetic foot ulcers is urging the appearance of an effective biomedical drug. Senescence is one of the major reasons of aging-induced decline in the diabetic wound. Our previous studies have demonstrated the anti-senescence effect of secretomes derived from human fetal mesenchymal stem cells (hfMSC). The present study tends to explore the potential role of hfMSC secretome (HFS) in wound healing through anti-aging. Meanwhile, we try to overcome several obstacles in the clinical application of stem cell secretome. A verticle bioreactor and microcarriers are employed to expand hfMSC and produce the HFS on a large scale. The HFS was then subjected to lyophilization (L-HFS). The PLGA (poly lactic-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.