Evidence map›Paper›PMID 36684079›Full record

ArticleBioengineering & translational medicine2023

ε-poly-L-lysine-modified polydopamine nanoparticles for targeted photothermal therapy of drug-resistant bacterial keratitis.

Wenjie Fan, Haijie Han, Zhouyu Lu, Yue Huang, Yin Zhang, Yaoyao Chen, Xiaobo Zhang, Jian Ji, Ke Yao

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Nanotechnology-Based Treatment for Ophthalmic Diseases.International journal of nanomedicine · 2026
    Review
  3. Recent Advances in Nanozymes Toward Diabetic Foot Ulcers.International journal of nanomedicine · 2026
    Review
  4. CuJournal of nanobiotechnology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Functionalization of and through Melanin: Strategies and Bio-Applications.International journal of molecular sciences · 2023
    Review
  13. Journal of materials chemistry. B · 2023
    Article
  14. Review
  15. Article
  16. Non-antibiotic management of bacterial keratitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenjie FanEye Center, the Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou People's Republic of China.
Haijie HanEye Center, the Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou People's Republic of China.
Zhouyu LuEye Center, the Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou People's Republic of China.
Yue HuangMOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering Zhejiang University Hangzhou People's Republic of China.
Yin ZhangEye Center, the Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou People's Republic of China.
Yaoyao ChenEye Center, the Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou People's Republic of China.
Xiaobo ZhangEye Center, the Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou People's Republic of China.
Jian JiMOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering Zhejiang University Hangzhou People's Republic of China.ORCID https://orcid.org/0000-0001-9870-4038
Ke YaoEye Center, the Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou People's Republic of China.ORCID https://orcid.org/0000-0002-6764-7365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial keratitis can lead to intraocular infection and even blindness without prompt and potent treatments. Currently, clinical abuse of antibiotics encouraged the evolution of resistant bacteria. Conventional antibiotic eye drops based keratitis treatment has been heavily restricted due to the lack of bactericidal efficiency and easy induction of bacterial resistance. Hence, developing an effective treatment strategy for bacterial keratitis is of great significance. In this work, we investigated ε-poly-l-lysine (EPL)-modified polydopamine (PDA) nanoparticles (EPL@PDA NPs)-mediated antibacterial photothermal therapy (aPTT), to cope with methicillin-resistant

Indexed as

drug‐resistant bacteriakeratitisphotothermal therapypolydopamineε‐poly‐l‐lysine

Identifiers

PMID36684079
PMCPMC9842021

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.