ArticleFrontiers in psychiatry2022
Use of antipsychotic medication and its relationship with bone mineral density: A population-based study of men and women.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Maternal Administration of Aripiprazole Impedes the Appendicular Skeletal Growth of Rat Fetuses: A Teratological and Histomorphometrical Assessment.Biomedicines · 2026Article
- Psychotropic medication use and bone loss in men: longitudinal study.BJPsych open · 2026Article
- Drug-Induced Osteoporosis.Journal of clinical medicine · 2026Review
- Analysis of the Influencing Factors of Aripiprazole and Risperidone on Bone Mass Health in Patients with Chronic Schizophrenia: A Cross-Sectional Study.Neuropsychiatric disease and treatment · 2026Article
- Linking the relationship between drug-induced osteoporosis and the gut microbiota.Frontiers in endocrinology · 2026Review
- Novel hypnotics use and hip fracture risk in middle-aged and older adults: A large, population-based cohort study in Japan.PCN reports : psychiatry and clinical neurosciences · 2025Article
- The Association Between Antipsychotics and Bone Fragility: An Updated Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- Antipsychotic medication use and fracture: a case-control study.Scientific reports · 2023Article
- Antipsychotic medication use in association with quantitative heel ultrasound (QUS).Bone reports · 2023Article
- Biofabrication of functional bone tissue: defining tissue-engineered scaffolds from nature.Frontiers in bioengineering and biotechnology · 2023Review
- Antipsychotic-induced bone loss: the role of dopamine, serotonin and adrenergic receptor signalling.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Schizophrenia has been shown to be associated with reduced bone mineral density (BMD) and higher fracture risk. However, less is known whether antipsychotic treatment is associated with reduced BMD. Thus, we aimed to examine associations between antipsychotic use and BMD among men and women drawn from the general population. Methods: This cross-sectional study involved 793 women and 587 men enrolled in the Geelong Osteoporosis Study (GOS). BMD was determined using dual-energy X-ray absorptiometry at the spine and hip. Information regarding socio-economic status (SES), current medication and/or supplementation use, lifestyle factors, and anthropometry was collected. Association between antipsychotic use and BMD was determined using linear regression after adjusting for potential confounders. Results: Of the group, 33 women (4.2%) and 16 men (2.7%) currently used antipsychotics. Age was identified as an effect modifier in the association between antipsychotic use and BMD for women. Amongst women aged < 60 years, adjusted mean BMD was 11.1% lower at the spine [1.139 (95%CI 1.063-1.216) vs. 1.250 (95%CI 1.223-1.277) g/cm Conclusion: Our data suggest that antipsychotic medication use is associated with reduced BMD in younger women but not older women or men.
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