Evidence map›Paper›PMID 36684000›Full record

ArticleFrontiers in psychiatry2022

Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms.

Stefano Ferracuti, Antonio Del Casale, Andrea Romano, Ida Gualtieri, Martina Lucignani, Antonio Napolitano, Martina Nicole Modesti, Andrea Buscajoni, Teodolinda Zoppi, Georgios D Kotzalidis and 8 more

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Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Stefano FerracutiDepartment of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza University, Rome, Italy.
Antonio Del CasaleDepartment of Dynamic and Clinical Psychology, and Health Studies, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Andrea RomanoDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Ida GualtieriDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Martina LucignaniIRCCS Bambino Gesù, Rome, Italy.
Antonio NapolitanoIRCCS Bambino Gesù, Rome, Italy.
Martina Nicole ModestiUnit of Psychiatry, Sant'Andrea University Hospital, Rome, Italy.
Andrea BuscajoniDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Teodolinda ZoppiDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Georgios D KotzalidisDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Lorenza ManelfiDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Eleonora de PisaUnit of Psychiatry, Sant'Andrea University Hospital, Rome, Italy.
Paolo GirardiDepartment of Dynamic and Clinical Psychology, and Health Studies, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Gabriele MandarelliDepartment of Interdisciplinary Medicine, Section of Criminology and Forensic Psychiatry, University of Bari, Bari, Italy.
Giovanna ParmigianiDepartment of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza University, Rome, Italy.
Maria Camilla Rossi-EspagnetDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Maurizio PompiliUnit of Psychiatry, Sant'Andrea University Hospital, Rome, Italy.
Alessandro BozzaoDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Interest in identifying the clinical implications of the neuropathophysiological background of schizophrenia is rising, including changes in cortical gyrification that may be due to neurodevelopmental abnormalities. Inpatients with schizophrenia can show abnormal gyrification of cortical regions correlated with the symptom severity. Methods: Our study included 36 patients that suffered an acute episode of schizophrenia and have undergone structural magnetic resonance imaging (MRI) to calculate the local gyrification index (LGI). Results: In the whole sample, the severity of symptoms significantly correlated with higher LGI in different cortical areas, including bilateral frontal, cingulate, parietal, temporal cortices, and right occipital cortex. Among these areas, patients with low hostility symptoms (LHS) compared to patients with high hostility symptoms (HHS) showed significantly lower LGI related to the severity of symptoms in bilateral frontal and temporal lobes. Discussion: The severity of psychopathology correlated with higher LGI in large portions of the cerebral cortex, possibly expressing abnormal neural development in schizophrenia. These findings could pave the way for further studies and future tailored diagnostic and therapeutic strategies.

Indexed as

gyrificationhostilitymagnetic resonance imagingneuroimagingpsychosisschizophrenia

Identifiers

PMID36684000
PMCPMC9846757

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