Evidence map›Paper›PMID 36683760›Full record

ArticleRegenerative biomaterials2023

Layer-by-layer assembly of procyanidin and collagen promotes mesenchymal stem cell proliferation and osteogenic differentiation

Zhibiao Bai, Kai Hu, Zeyu Shou, Jiahuan Yu, Hongming Meng, Han Zhou, Liangyan Chen, Tiantian Yu, Ruofei Lu, Na Li and 1 more

Open access · goldAbstract read
In one paragraph

Article in Regenerative biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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  15. [Effect of Wnt/β-catenin signaling pathway in neural differentiation of human bone marrow mesenchymal stem cells].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Zhibiao BaiDepartment of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Kai HuWenzhou Medical University, Wenzhou 325000, P.R. China.
Zeyu ShouWenzhou Medical University, Wenzhou 325000, P.R. China.
Jiahuan YuWenzhou Medical University, Wenzhou 325000, P.R. China.
Hongming MengWenzhou Medical University, Wenzhou 325000, P.R. China.
Han ZhouWenzhou Medical University, Wenzhou 325000, P.R. China.
Liangyan ChenWenzhou Medical University, Wenzhou 325000, P.R. China.
Tiantian YuWenzhou Key Laboratory of Perioperative Medicine, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, P.R. China.
Ruofei LuXinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, P.R. China.
Na LiWenzhou Key Laboratory of Perioperative Medicine, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, P.R. China.
Chun ChenDepartment of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.ORCID https://orcid.org/0000-0002-7856-6405
Wenzhou Medical University · CNWenzhou University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collagen, commonly used in tissue engineering, is widespread in various tissues. During bone tissue regeneration, collagen can stimulate the cellular response and determine the fate of cells. In this work, we integrated collagen type II with procyanidin (PC) onto an implant coating by applying a layer-by-layer technique to demonstrate that collagen and PC can participate in the construction of new biomaterials and serve as multifunctional components. The effects of PC/collagen multilayers on the viability of cocultured bone marrow mesenchymal stem cells (BMSCs) were analyzed by cell counting kit-8 analysis and phalloidin staining. The reactive oxygen species level of BMSCs was revealed through immunofluorescent staining and flow cytometry. Osteogenesis-related genes were detected, and

Indexed as

bone marrow mesenchymal stem cellscoatingcollagenosteogenesisprocyanidine

Identifiers

PMID36683760
PMCPMC9847536
OpenAlexW4312179708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.