Evidence map›Paper›PMID 36683454›Full record

Trial reportPediatrics2023

Food Allergy Management for Adolescents Using Behavioral Incentives: A Randomized Trial.

Roxanne Dupuis, Rachel Feuerstein-Simon, Terri F Brown-Whitehorn, Jonathan M Spergel, Kevin G Volpp, Xochitl Luna Marti, Andrea B Troxel, Zachary F Meisel, Cynthia J Mollen, Erica L Kenney and 3 more

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Incidence of food allergic reactions among adolescents engaged in food allergy management.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Trial
  3. Review
  4. First-in-class intranasal epinephrine spray for anaphylaxis: Dose finding clinical study.The journal of allergy and clinical immunology. Global · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Roxanne DupuisHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Rachel Feuerstein-SimonUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Terri F Brown-WhitehornThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Jonathan M SpergelThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Kevin G VolppUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Xochitl Luna MartiUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Andrea B TroxelNYU School of Medicine, New York, New York.
Zachary F MeiselThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Cynthia J MollenThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Erica L KenneyHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Jason BlockHarvard Pilgrim/Harvard Medical School, Boston, Massachusetts.
Steven L GortmakerHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Carolyn C CannuscioUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Children's Hospital of Philadelphia · USHarvard University · USUniversity of Pennsylvania · US

Funding

Safer Food Allergy Management for AdolescentsR21HD088941 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI CANNUSCIO, CAROLYN CHRISTA · 2017 to 2018
$461k
NICHD NIH HHS R21 HD088941
6 · The paper itself

Abstract

objectiveWe sought to evaluate the use of behavioral economics approaches to promote the carrying of epinephrine auto-injectors (EAIs) among adolescents with food allergies. We hypothesized that adolescents who receive frequent text message nudges (Intervention 1) or frequent text message nudges plus modest financial incentives (Intervention 2) would be more likely to carry their epinephrine than members of the usual care control group.

methodsWe recruited 131 adolescents ages 15 to 19 with a food allergy and a current prescription for epinephrine to participate in a cohort multiple randomized controlled trial. Participants were randomly assigned to participate in Intervention 1, Intervention 2, or to receive usual care. The primary outcome was consistency of epinephrine-carrying, measured as the proportion of checkpoints at which a participant could successfully demonstrate they were carrying their EAI, with photo-documentation of the device.

resultsDuring Intervention 1, participants who received the intervention carried their EAI 28% of the time versus 38% for control group participants (P = .06). During Intervention 2, participations who received the intervention carried their EAI 45% of the time versus 23% for control group participants (P = .002).

conclusionsText message nudges alone were unsuccessful at promoting EAI-carrying but text message nudges combined with modest financial incentives almost doubled EAI-carriage rates among those who received the intervention compared with the control group. However, even with the intervention, adolescents with food allergies carried their EAI <50% of the time. Alternative strategies for making EAIs accessible to adolescents at all times should be implemented.

Indexed as

AnaphylaxisFood HypersensitivityAdolescentAdultEpinephrineHumansMotivationSelf AdministrationYoung AdultEpinephrine

Identifiers

PMID36683454
PMCPMC9890392
OpenAlexW4317734086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.