Evidence map›Paper›PMID 36683340›Full record

ArticleASN neuro

Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice.

Fei Zeng, Karsten Parker, Yanqiang Zhan, Matthew Miller, Meng-Yang Zhu

Open access · goldAbstract read
In one paragraph

Article in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Fei ZengDepartment of Neurology, Renmin Hospital of the Wuhan University, Wuhan, China.
Karsten ParkerDepartments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, Johnson City, TN, USA.
Yanqiang ZhanDepartment of Neurology, Renmin Hospital of the Wuhan University, Wuhan, China.
Matthew MillerDepartments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, Johnson City, TN, USA.
Meng-Yang ZhuDepartments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, Johnson City, TN, USA.ORCID 0000-0002-5403-1270
East Tennessee State University · US

Funding

Restoration of noradrenergic and dopaminergic functions in the brain of aged rats.R15AG055107 · NIA · EAST TENNESSEE STATE UNIVERSITY · PI ZHU, MENG-YANG · 2018 to 2018
$444k
NIA NIH HHS R15 AG055107
6 · The paper itself

Abstract

summary statementThe present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.

Indexed as

DNA DamageOxidative StressParkinson DiseaseAnimalsBiomarkersBrainDisease Models, AnimalMiceVesicular Monoamine Transport ProteinsBiomarkersSlc18a2 protein, mouseVesicular Monoamine Transport ProteinsATM/ATRdopamineDNA damagelocus coeruleusoxidation stresssubstantia nigraγH2AX

Identifiers

PMID36683340
PMCPMC9880594
OpenAlexW4317721557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.