Evidence map›Paper›PMID 36683325›Full record

ArticlePlatelets2023

The CalDAG-GEFI/Rap1/αIIbβ3 axis minimally contributes to accelerated platelet clearance in mice with constitutive store-operated calcium entry.

Robert H Lee, David J Rocco, Bernhard Nieswandt, Wolfgang Bergmeier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Platelets, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Robert H LeeDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0001-9871-0593
David J RoccoUNC Blood Research Center, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-2580-1790
Bernhard NieswandtInstitute of Experimental Biomedicine I, University Hospital Würzburg, Würzburg, Germany.ORCID 0000-0003-1454-7413
Wolfgang BergmeierDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-1211-8861
University of North Carolina at Chapel Hill · USUniversity of Würzburg · DE

Funding

Small GTPases in the biology of platelets and megakaryocytesR35HL144976 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BERGMEIER, WOLFGANG · 2019 to 2025
$5.4M
NHLBI NIH HHS R35 HL144976
6 · The paper itself

Abstract

Circulating platelets maintain low cytosolic Ca

Indexed as

Blood PlateletsCalciumGuanine Nucleotide Exchange FactorsPlatelet Glycoprotein GPIIb-IIIa ComplexAnimalsGTPase-Activating ProteinsMicerap1 GTP-Binding ProteinsSignal TransductionThrombocytopeniaCalciumGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsPlatelet Glycoprotein GPIIb-IIIa Complexrap1 GTP-Binding ProteinsRap1 protein, mouseRASA3 protein, mouseRasgrp2 protein, mouseCalciumplateletRap1Stim1, thrombocytopenia

Identifiers

PMID36683325
PMCPMC10032033
OpenAlexW4317721677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.