Evidence map›Paper›PMID 36683148›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.

Xiaoquan Rao, Michael Razavi, Georgeta Mihai, Yingying Wei, Zachary Braunstein, Matthew B Frieman, Xiao Jian Sun, Quan Gong, Jun Chen, Gang Zhao and 5 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4-Targeted Probe.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Xiaoquan RaoDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China.
Michael RazaviCardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Georgeta MihaiBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Yingying WeiCardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Zachary BraunsteinWexner Medical Center, The Ohio State University, Columbus, Ohio, 43210, USA.
Matthew B FriemanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA.
Xiao Jian SunDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA.
Quan GongDepartment of Immunology, School of Medicine, Yangtze University, Jingzhou, Hubei, 434023, P. R. China.
Jun ChenSinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, P. R. China.
Gang ZhaoDepartment of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, 250021, P. R. China.
Zheng LiuDepartment of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China.
Michael J QuonDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA.
Lingli DongDivision of Rheumatology and Immunology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China.
Sanjay RajagopalanCardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Jixin ZhongCardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio, 44106, USA.ORCID 0000-0002-3534-7480
Case Western Reserve University · USTongji Hospital · CNUniversity of Maryland, Baltimore · USThe Ohio State University Wexner Medical Center · USBrigham and Women's Hospital · USHubei University of Medicine · CNShandong University · CNYangtze University · CN

Funding

Regulation of DPP4 and its non-catalytic function in type 2 diabetesK01DK105108 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHONG, JIXIN · 2015 to 2017
$443k
Role of DPP4-ADA interaction in obesity-induced inflammationR03DK119680 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI ZHONG, JIXIN · 2019 to 2020
$154k
A role of DPP4 in T cell trafficking and vascular inflammationR01HL142643 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ZHONG, JIXIN · 2020 to 2020
$21k
NHLBI NIH HHS R01 HL142643NIDDK NIH HHS K01 DK105108NIDDK NIH HHS R03 DK119680NIH HHS K01DK105108NIH HHS R01HL142643NIH HHS R03DK119680
6 · The paper itself

Abstract

T cells play a crucial role in atherosclerosis, with its infiltration preceding the formation of atheroma. However, how T-cell infiltration is regulated in atherosclerosis remains largely unknown. Here, this work demonstrates that dipeptidyl peptidase-4 (DPP4) is a novel regulator of T-cell motility in atherosclerosis. Single-cell ribonucleic acid (RNA) sequencing and flow cytometry show that CD4

Indexed as

AtherosclerosisDipeptidyl-Peptidase IV InhibitorsPlaque, AtheroscleroticAnimalsDipeptidyl Peptidase 4MiceT-LymphocytesUbiquitin-Protein LigasesDipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsDpp4 protein, mouseMid1 protein, mouseUbiquitin-Protein Ligasesatherosclerosisdipeptidyl peptidase-4midline-1migrationT cell

Identifiers

PMID36683148
PMCPMC10037965
OpenAlexW4317780816

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read31
identifiers read2
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.