Evidence map›Paper›PMID 36683084›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Analysis of LAP

Haobing Cai, Yu Liu, Xiaohua Dong, Fei Jiang, Hongliang Li, Song Ouyang, Weifan Yin, Ting He, Qiuming Zeng, Huan Yang

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Spectral Flow Cytometry: The Current State and Future of the Technology.International journal of molecular sciences · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Haobing Cai *Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yu Liu *Brain Hospital of Hunan Province (The Second People's Hospital of Hunan Province), Changsha, China.
Xiaohua DongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Fei JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hongliang LiAcupuncture and Tuina Rehabilitation Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Song OuyangMedical Center of Neurology, The First Hospital of Changsha City, South China University, Changsha, China.
Weifan YinThe Second Xiangya Hospital, Central South University, Changsha, China.
Ting HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Qiuming ZengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China. zengqiuming1983@126.com.
Huan YangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China. 403850@csu.edu.cn.ORCID http://orcid.org/0000-0002-8690-2544
Central South University · CNHunan University · CNSecond People Hospital of Hunan · CNThe First Hospital of Changsha · CN

Funding

Changsha Municipal Natural Science Foundation kq2007037Hunan Academician Expert Workstation (Shi Xuemin) Open-end Fund Project 2019YSZJJ12National Natural Science Foundation of China 81801203Natural Science Foundation of Hunan Province 2022JJ40724Science and Technology Innovation Guidance Project of Hunan Province 2020SK53009
6 · The paper itself

Abstract

introductionNeuromyelitis optica spectrum disorder (NMOSD) is a group of antibody-mediated inflammatory demyelinating central nervous system diseases. T lymphocytes participate in NMOSD pathogenesis, with regulatory T cells (Treg) being the core in maintaining immune homeostasis. Studies have revealed that different Treg subsets play different roles in autoimmune diseases. The distribution of LAP

methodsThis study reviewed 22 NMOSD patients and 20 normal controls. Flow cytometric analysis was utilized to detect subsets of Treg cells expressing Foxp3, Helios, LAP, or GARP in peripheral blood. ELISA was used to detect plasma TGF-β1 and IL-10. In addition, changes in the proportion of Treg cell subsets before and after glucocorticoid treatment in 10 patients were analyzed.

resultsCompared with healthy controls, LAP and GARP expressions were significantly downregulated in the peripheral blood of NMOSD patients. TGF-β1 expression in NMOSD patients was lower and was positively correlated with the ratio of CD4

conclusionsThe proportion of Treg cells expressing LAP and GARP is downregulated, implying that Treg cells with the best inhibitory function are insufficient to maintain autoimmune homeostasis in NMOSD patients. Upregulation of Treg cells expressing LAP and GARP in NMOSD patients may be one of the mechanisms of glucocorticoid treatment.

Indexed as

Membrane ProteinsNeuromyelitis OpticaT-Lymphocytes, RegulatoryTransforming Growth Factor beta1GlucocorticoidsHumansGlucocorticoidsLRRC32 protein, humanMembrane ProteinsTGFB1 protein, humanTransforming Growth Factor beta1Glycoprotein A repetitions predominantLatency-associated peptideNeuromyelitis optica spectrum disordersRegulatory T cellsTransforming growth factor-β1

Identifiers

PMID36683084
OpenAlexW4317715931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.