Evidence map›Paper›PMID 36682908›Full record

Trial reportInternational dental journal2023

Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical Trial.

Faith Miaomiao Zheng, Iliana Gehui Yan, Duangporn Duangthip, Edward Chin Man Lo, Sherry Shiqian Gao, Chun Hung Chu

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International dental journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04399369 (Preventing Early Childhood Caries with Silver Diamine Fluoride - a 12-month Randomised Clinical Trial), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04399369 phase2completednot on this map

Preventing Early Childhood Caries with Silver Diamine Fluoride - a 12-month Randomised Clinical Trial

TypeinterventionalSponsorThe University of Hong KongRan2020 to 2023Enrolled688ConditionsDental CariesArmsSDF, NaF
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Long-term evaluation of the success rate of different treatment modalities on MIH-affected teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Faith Miaomiao ZhengFaculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Iliana Gehui YanFaculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Duangporn DuangthipFaculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Edward Chin Man LoFaculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Sherry Shiqian GaoFaculty of Dentistry, The University of Hong Kong, Hong Kong, China; Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China. Electronic address: sherrysgao@xmu.edu.cn.
Chun Hung ChuFaculty of Dentistry, The University of Hong Kong, Hong Kong, China. Electronic address: chchu@hku.hk.
University of Hong Kong · HKXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis clinical trial aimed to compare the caries-preventive effect of annual application of 38% silver diamine fluoride solution (SDF) with 5% sodium fluoride varnish (FV) to the anterior primary teeth of children. The hypothesis was that SDF was superior to FV at 1 year. Secondary objectives were to determine the child's cooperation and the parent's satisfaction and assess adverse effects.

methodWe recruited 688 3- to 4-year-old children and randomly allocated them to receive SDF or FV (positive control) on their 6 upper anterior teeth. Tooth-surface status was recorded using the decayed, missing, and filled surfaces index. A trained observer rated the child's cooperation as "totally cooperative" or "not totally cooperative." We used a questionnaire to determine the parent's satisfaction as "satisfied," "neutral," or "dissatisfied." Adverse effects (yes/no) were evaluated 1 day and about 1 year after treatment.

resultsOf the children, 434 (SDF, n = 209; FV, n = 225) completed the trial. The mean new decayed tooth surfaces developed for SDF and FV groups were 0.4 ± 1.5 and 0.4 ± 1.3, respectively (P = .65). Child's cooperation for SDF and FV therapy was 71% (244/344) and 70% (241/344), respectively (P = .89). Parent's satisfaction for SDF and FV therapy was 71% (148/209) and 69% (155/225), respectively (P = .29). Adverse effects were found neither at 1 day nor at about 1 year after treatment for either treatment arm.

conclusionsSDF is not superior to FV for caries prevention in primary upper anterior teeth at 1-year follow-up. Child's cooperation and parent's satisfaction were similarly high with SDF and FV therapy at 1-year follow-up. Neither short-term nor long-term adverse effects were observed. This study is registered at ClinicalTrials.gov (NCT04399369).

Indexed as

Dental CariesFluorides, TopicalCariostatic AgentsChild, PreschoolDental Caries SusceptibilityHumansQuaternary Ammonium CompoundsSilver CompoundsCariostatic AgentsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluorideCariesChildrenEarly childhoodOral healthPreventionSilver diamine fluoride

Identifiers

PMID36682908
PMCPMC10509425
OpenAlexW4317538424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.