ArticleJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy2023
Diagnostic significance of secondary bacteremia in patients with COVID-19.
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Article in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Candidemia Following Severe COVID-19 in Hospitalised and Critical Ill Patients: A Systematic Review and Meta-Analysis.Mycoses · 2024Pooled it
- Incidence and Temporal Dynamics of Combined Infections in SARS-CoV-2-Infected Patients With Risk Factors for Severe Complications.Journal of Korean medical science · 2025Article
- Article
- Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients.Viruses · 2024Article
- Review
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Authors and funding
100 authors at 20 institutions in 1 country.
Kensuke NakagawaraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hirofumi KamataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address: h-kamata@a2.keio.jp.
Shotaro ChubachiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Hiromu TanakaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ho LeeDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Shiro OtakeDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Takahiro FukushimaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Tatsuya KusumotoDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Atsuho MoritaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Shuhei AzekawaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Mayuko WataseDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Takanori AsakuraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Tokyo, Japan; Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan.
Katsunori MasakiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Makoto IshiiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akifumi EndoClinical Research Center, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Ryuji KoikeClinical Research Center, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Hiroyasu IshikuraDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University Hospital, Fukuoka, Japan.
Tohru TakataDepartment of Infection Control, Fukuoka University, Fukuoka, Japan.
Yasushi MatsushitaDepartment of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Norihiro HaradaDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Hiroyuki KokutouFukujuji Hospital, Kiyose, Japan.
Takashi YoshiyamaFukujuji Hospital, Kiyose, Japan.
Kensuke KataokaDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Japan.
Yoshikazu MutohDepartment of Infectious Diseases, Tosei General Hospital, Seto, Japan.
Masayoshi MiyawakiDepartment of Internal Medicine, JCHO (Japan Community Health Care Organization) Saitama Medical Center, Saitama, Japan.
Soichiro UedaDepartment of Internal Medicine, JCHO (Japan Community Health Care Organization) Saitama Medical Center, Saitama, Japan.
Hiroshi OnoDivision of Infectious Diseases and Respiratory Medicine, Kumamoto Medical Center, Kumamoto, Japan.
Takuya OnoEmergency and Critical Care Medicine, Tokyo Women's Medical University Adachi Medical Center, Tokyo, Japan.
Tomohisa ShokoEmergency and Critical Care Medicine, Tokyo Women's Medical University Adachi Medical Center, Tokyo, Japan.
Hiroyuki MuranakaDivision of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Kodai KawamuraDivision of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Nobuaki MoriDepartment of General Internal Medicine and Infectious Diseases, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Takao MochimaruDepartment of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Mototaka FukuiUji-Tokushukai Medical Center, Uji, Japan.
Yusuke ChiharaUji-Tokushukai Medical Center, Uji, Japan.
Yoji NagasakiDepartment of Respirology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Masaki OkamotoDepartment of Respirology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Masaru AmishimaDepartment of Respiratory Medicine, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
Toshio OdaniDepartment of Rheumatology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
Mayuko TaniIshikawa Prefectural Central Hospital, Kanazawa, Japan.
Koichi NishiIshikawa Prefectural Central Hospital, Kanazawa, Japan.
Yuya ShiraiDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Ryuya EdahiroDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Akira AndoDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Naozumi HashimotoDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shinji OguraDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Yuichiro KitagawaDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Toshiyuki KitaNational Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Takashi KagayaNational Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Yasuhiro KimuraDepartment of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
Naoki MiyazawaDepartment of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
Tomoya TsuchidaDivision of General Internal Medicine, Department of Internal Medicine, St. Marianna University School of Medicine Kawasaki, Japan.
Shigeki FujitaniDepartment of Emergency and Critical Care Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Koji MurakamiDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hirohito SanoDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yuki SatoDepartment of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Yoshinori TaninoDepartment of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Ryo OtsukiDepartment of Respiratory Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan.
Shuko MashimoDepartment of Respiratory Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan.
Mizuki KuramochiDepartment of Gastroenterology, National Hospital Organization Saitama National Hospital, Wako, Saitama, Japan.
Yasuo HosodaDepartment of Gastroenterology, National Hospital Organization Saitama National Hospital, Wako, Saitama, Japan.
Yoshinori HasegawaDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Tetsuya UedaDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Yotaro TakakuDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Takashi IshiguroDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Akiko FujiwaraDepartment of Medicine, Division of Allergology and Respiratory Medicine, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Naota KuwaharaDepartment of Medicine, Division of Allergology and Respiratory Medicine, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Hideya KitamuraDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Eri HagiwaraDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Yasushi NakamoriDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Osaka, Japan.
Fukuki SaitoDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Osaka, Japan.
Yuta KonoDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Shinji AbeDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Tomoo IshiiTokyo Medical University Ibaraki Medical Center, Inashiki, Japan.
Takehiko OhbaDepartment of Respiratory Medicine, Ome Municipal General Hospital, Ome, Tokyo, Japan.
Yu KusakaDepartment of Respiratory Medicine, Ome Municipal General Hospital, Ome, Tokyo, Japan.
Hiroko WatanabeDivision of Respiratory Medicine, Tsukuba Kinen General Hospital, Ibaraki, Japan.
Makoto MasudaDepartment of Respiratory Medicine, Fujisawa City Hospital, Fujisawa, Japan.
Hiroki WatanabeDepartment of Respiratory Medicine, Fujisawa City Hospital, Fujisawa, Japan.
Yoshifumi KimizukaDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Akihiko KawanaDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Yu KasamatsuDepartment of Infection Control and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Satoru HashimotoDepartment of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Tomomi TakanoSchool of Veterinary Medicine, Kitasato University, Towada, Japan.
Kazuhiko KatayamaLaboratory of Viral Infection I, Department of Infection Control and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Masumi AiDepartment of Insured Medical Care Management, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Toshiro SatoDepartment of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.
Katsushi TokunagaGenome Medical Science Project (Toyama), National Center for Global Health and Medicine, Tokyo, Japan.
Seiya ImotoDivision of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Akinori KimuraInstitute of Research, Tokyo Medical and Dental University, Tokyo, Japan.
Satoru MiyanoM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Naoki HasegawaDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Seishi OgawaDepartment of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Takanori KanaiDivision of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Koichi FukunagaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Japan COVID-19 Task Force
Keio University · JPFujisawa City Hospital · JPThe University of Osaka · JPTokyo Medical and Dental University Hospital · JPFukujuji Hospital · JPFukushima Medical University · JPIshikawa Prefectural Central Hospital · JPJuntendo University · JPKanagawa Cardiovascular and Respiratory Center · JPKanazawa Medical Center · JPKansai Medical University · JPKitasato University · JPKyoto Prefectural University of Medicine · JPNagoya University · JPNational Defense Medical College · JPNational Hospital Organization · JPNational Hospital Organization Hokkaido Medical Center · JPNational Kyushu Medical Center · JPOme Municipal General Hospital · JPSaiseikai Ibaraki Hospital · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe investigated the occurrence of non-respiratory bacterial and fungal secondary infections, causative organisms, impact on clinical outcomes, and association between the secondary pathogens and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19).
methodsThis was a retrospective cohort study that included data from inpatients with COVID-19 from multiple centers participating in the Japan COVID-19 Taskforce (April 2020 to May 2021). We obtained demographic, epidemiological, and microbiological data throughout the course of hospitalization and analyzed the cases of COVID-19 complicated by non-respiratory bacterial infections.
resultsOf the 1914 patients included, non-respiratory bacterial infections with COVID-19 were diagnosed in 81 patients (4.2%). Of these, 59 (3.1%) were secondary infections. Bacteremia was the most frequent bacterial infection, occurring in 33 cases (55.9%), followed by urinary tract infections in 16 cases (27.1%). Staphylococcus epidermidis was the most common causative organism of bacteremia. Patients with COVID-19 with non-respiratory secondary bacterial infections had significantly higher mortality, and a multivariate logistic regression analysis demonstrated that those with bacteremia (aOdds Ratio = 15.3 [5.97-39.1]) were at higher risk of death. Multivariate logistic regression analysis showed that age, male sex, use of steroids to treat COVID-19, and intensive care unit admission increased the risk for nosocomial bacteremia.
conclusionsSecondary bacteremia is an important complication that may lead to poor prognosis in cases with COVID-19. An appropriate medical management strategy must be established, especially for patients with concomitant predisposing factors.
Indexed as
BacteremiaBacterial InfectionsCoinfectionCOVID-19MycosesCOVID-19 TestingHumansMaleRetrospective StudiesBacteremiaFungemiaMortalitySARS-CoV-2 infectionSecondary infection
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