Evidence map›Paper›PMID 36682396›Full record

ArticleMagnetic resonance imaging2023

Brain iron imaging markers in the presence of white matter hyperintensities.

Kyle D Murray, Madalina E Tivarus, Giovanni Schifitto, Md Nasir Uddin, Jianhui Zhong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kyle D MurrayDepartment of Physics and Astronomy, University of Rochester, Rochester, NY, USA.
Madalina E TivarusDepartment of Imaging Sciences, University of Rochester, Rochester, NY, USA; Department of Neuroscience, University of Rochester, Rochester, NY, USA.
Giovanni SchifittoDepartment of Imaging Sciences, University of Rochester, Rochester, NY, USA; Department of Neurology, University of Rochester, Rochester, NY, USA; Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, USA.
Md Nasir UddinDepartment of Neurology, University of Rochester, Rochester, NY, USA.
Jianhui ZhongDepartment of Physics and Astronomy, University of Rochester, Rochester, NY, USA; Department of Imaging Sciences, University of Rochester, Rochester, NY, USA; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA. Electronic address: Jianhui.Zhong@rochester.edu.
University of Rochester · US

Funding

Role of Myeloid Cells in Cerebrovascular Permeability and Reactivity in Older HIV Infected IndividualsR01AG054328 · NIA · UNIVERSITY OF ROCHESTER · PI MAGGIRWAR, SANJAY B., SCHIFITTO, GIOVANNI · 2017 to 2021
$3.5M
NIA NIH HHS R01 AG054328
6 · The paper itself

Abstract

purposeTo investigate the relationship between pathological brain iron deposition and white matter hyperintensities (WMHs) in cerebral small vessel disease (CSVD), via Monte Carlo simulations of magnetic susceptibility imaging and the development of a novel imaging marker called the Expected Iron Coefficient (EIC).

methodsA synthetic pathological model of a different number of impenetrable spheres at random locations was employed to represent pathological iron deposition. The diffusion process was simulated with a Monte Carlo method with adjustable parameters to manipulate sphere size, distribution, and extracellular properties. Quantitative susceptibility mapping (QSM) was performed in a clinical dataset to study CSVD to derive and evaluate QSM, R2*, the iron microenvironment coefficient (IMC), and the EIC in the presence of WMHs.

resultsThe simulations show that QSM signals increase in the presence of increased tissue iron, confirming that the EIC increases with pathology. Clinical results demonstrate that while QSM, R2*, and the IMC do not show significant differences in brain iron, the EIC does in the context of CSVD.

conclusionThe EIC is more sensitive to subtle changes in brain iron deposition caused by pathology, even when QSM, R2*, and the IMC fail.

Indexed as

Cerebral Small Vessel DiseasesLeukoaraiosisWhite MatterBrainBrain MappingGray MatterHumansImage Interpretation, Computer-AssistedIronMagnetic Resonance ImagingIronBrain ironCerebral small vessel diseaseMonte Carlo simulationsQuantitative susceptibility mappingR2*White matter hyperintensities

Identifiers

PMID36682396
PMCPMC9968496
OpenAlexW4317492901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.