Evidence map›Paper›PMID 36682292›Full record

ArticleEuropean journal of medicinal chemistry2023

SAR study of piperidine derivatives as inhibitors of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis.

Kaja Berg, Pooja Hegde, Venugopal Pujari, Marzena Brinkmann, David Z Wilkins, Tanya Parish, Dean C Crick, Courtney C Aldrich

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Menaquinone depletion resensitises bedaquiline-resistant tuberculosis.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Biofilm development ofMicrobiology spectrum · 2025
    Article
  4. Evolution of Small Molecule Inhibitors ofJournal of medicinal chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kaja BergDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street Southeast, Minneapolis, MN, 55455, USA.
Pooja HegdeDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street Southeast, Minneapolis, MN, 55455, USA.
Venugopal PujariMycobacteria Research Laboratories, Microbiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, CO, 80523, USA.
Marzena BrinkmannDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street Southeast, Minneapolis, MN, 55455, USA.
David Z WilkinsCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, 98109, USA.
Tanya ParishCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, 98109, USA.
Dean C CrickMycobacteria Research Laboratories, Microbiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, CO, 80523, USA. Electronic address: Dean.Crick@colostate.edu.
Courtney C AldrichDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street Southeast, Minneapolis, MN, 55455, USA. Electronic address: aldri015@umn.edu.
University of Minnesota · USColorado State University · USInfectious Disease Research Institute · US

Funding

Sterol/Hopanoid Biosynthesis: An Anti-TB Drug TargetR01AI049151 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI CRICK, DEAN C · 2001 to 2019
$4.1M
Menaquinone biosynthesis: a drug target in Gram-positive bacteriaR56AI049151 · NIAID · COLORADO STATE UNIVERSITY · PI CRICK, DEAN C · 2007 to 2007
$320k
NIAID NIH HHS R01 AI049151NIAID NIH HHS R56 AI049151
6 · The paper itself

Abstract

The electron transport chain (ETC) in the cell membrane consists of a series of redox complexes that transfer electrons from electron donors to acceptors and couples this electron transfer with the transfer of protons (H

Indexed as

Mycobacterium tuberculosisTuberculosisAntitubercular AgentsElectron TransportHumansNaphthols1,4-dihydroxy-2-naphthoic acidAntitubercular AgentsNaphthols1,4-dihydroxy-2-naphthoate prenyltransferaseMenAMenA inhibitorsMenaquinoneMtbMycobacterium tuberculosisPiperidine derivativesSAR

Identifiers

PMID36682292
PMCPMC9975056
OpenAlexW4317781168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.