ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Mortality Associations With DNA Methylation-Based Biological Aging and Physical Functioning Measures Across a 20-Year Follow-up Period.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Responsiveness of epigenetic aging biomarkers to longevity interventions in humans.Nature medicine · 2026Article
- Association between pace of aging estimated from blood DNA methylation and all-cause mortality: the HUNT study.Clinical epigenetics · 2026Article
- Comparing fourteen consensus biomarkers of aging: epigenetic pace of aging as the strongest predictor of mortality in BASE-II.Biomarker research · 2026Article
- Examining the Relationships Between Blood Cadmium, DNA Methylation Biomarker, Telomere Length, and Their Associations with Mortality in U.S. Adults.Life (Basel, Switzerland) · 2025Article
- Physical Activity Is Associated With Decreased Epigenetic Aging: Findings From the Health and Retirement Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study.JAMA network open · 2024Article
- Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells.Molecular human reproduction · 2024Review
- Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults.Clinical epigenetics · 2024Article
- Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status.Science advances · 2023Article
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7 authors.
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Abstract
backgroundMeasures of biological aging range from DNA methylation (DNAm)-based estimates to measures of physical abilities. The purpose of this study was to compare DNAm- and physical functioning-based measures of biological aging in predicting mortality.
methodsWe studied 63- to 76-year-old women (N = 395) from the Finnish Twin Study on Aging (FITSA). Participants' biological age (epigenetic clocks DNAm GrimAge and DunedinPACE) was estimated using blood DNAm data. Tests of physical functioning conducted under standardized laboratory conditions included the Timed Up and Go (TUG) test and 10-m walk test. Mortality hazard ratios were calculated per every 1 standard deviation (SD) increase in the predictor. Cox regression models were conducted for individuals and twin pairs, the latter controlling for underlying genetic effects. The models were adjusted for known lifestyle predictors of mortality.
resultsDuring the follow-up period (mean 17.0 years, range 0.2-20.3), 187 participants died. In both the individual-based and pairwise analyses, GrimAge and both functional biomarkers of aging were associated with mortality independent of family relatedness, chronological age, physical activity, body mass index, smoking, education, or chronic diseases. In a model including both the DNAm-based measures and functional biomarkers of aging, GrimAge and TUG remained predictive.
conclusionsThe findings suggest that DNAm GrimAge and the TUG test are strong predictors of mortality independent of each others and genetic influences. DNAm-based measures and functional tests capture different aspects of the aging process and thus complement each other as measures of biological aging in predicting mortality.
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