Evidence map›Paper›PMID 36681760›Full record

ArticleCommunications biology2023

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling.

Eric Schoger, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Möbius, Maren Sitte, Christof Lenz, Mostafa Samak and 6 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Eric Schoger *Institute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.ORCID http://orcid.org/0000-0002-5485-9828
Federico Bleckwedel *Institute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
Giulia GermenaGerman Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.ORCID http://orcid.org/0000-0001-7005-4272
Cheila RochaLaboratory Animal Science Unit, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, 37075, Göttingen, Germany.ORCID http://orcid.org/0000-0002-0148-9405
Petra TuchollaInstitute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
Izzatullo SobitovInstitute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
Wiebke MöbiusMax-Planck-Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.ORCID http://orcid.org/0000-0002-2902-7165
Maren SitteNGS Integrative Genomics Core Unit (NIG), University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.ORCID http://orcid.org/0000-0001-6510-2604
Christof LenzDepartment of Clinical Chemistry, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.ORCID http://orcid.org/0000-0002-0946-8166
Mostafa SamakGerman Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.
Rabea HinkelGerman Center for Cardiovascular Research (DZHK) partner site Göttingen, 37075, Göttingen, Germany.
Zoltán V VargaHCEMM-SU Cardiometabolic Immunology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1085, Budapest, Hungary.
Zoltán GiriczHCEMM-SU Cardiometabolic Immunology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1085, Budapest, Hungary.ORCID http://orcid.org/0000-0003-2036-8665
Gabriela SalinasNGS Integrative Genomics Core Unit (NIG), University Medical Center Göttingen (UMG), 37075, Göttingen, Germany.
Julia C GrossHealth and Medical University, D-14471, Potsdam, Germany.ORCID http://orcid.org/0000-0002-8939-5664
Laura C ZelarayánInstitute of Pharmacology and Toxicology, University Medical Center Göttingen (UMG), 37075, Göttingen, Germany. laura.zelarayan@med.uni-goettingen.de.ORCID http://orcid.org/0000-0002-9001-0346
Universitätsmedizin Göttingen · DEGerman Primate Center · DESemmelweis University · HUMax Planck Institute for Multidisciplinary SciencesUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant Wnt activation has been reported in failing cardiomyocytes. Here we present single cell transcriptome profiling of hearts with inducible cardiomyocyte-specific Wnt activation (β-cat

Indexed as

Extracellular VesiclesInduced Pluripotent Stem CellsAnimalsGene Expression ProfilingHumansMiceMyocytes, CardiacProteinsProteomicsProteostasisTranscriptomeProteins

Identifiers

PMID36681760
PMCPMC9867722
OpenAlexW4317651689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.