Evidence map›Paper›PMID 36681757›Full record

ArticleCommunications biology2023

Lateral line ablation by ototoxic compounds results in distinct rheotaxis profiles in larval zebrafish.

Kyle C Newton, Dovi Kacev, Simon R O Nilsson, Allison L Saettele, Sam A Golden, Lavinia Sheets

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

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  15. High-THCeNeuro · 2023
    Article
  16. Article
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  19. Article
  20. Hair cell toxicology: With the help of a little fish.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kyle C NewtonDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA. kylecnewton@gmail.com.ORCID 0000-0003-1499-0714
Dovi KacevScripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.
Simon R O NilssonDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Allison L SaetteleDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA.
Sam A GoldenDepartment of Biological Structure, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2104-2272
Lavinia SheetsDepartment of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA. sheetsl@wustl.edu.ORCID 0000-0001-5231-2450
University of Washington · USWashington University in St. Louis · USOregon Department of Fish and Wildlife · USScripps Institution of Oceanography · US

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Roles of the Synapse in Hair-Cell PathologyR01DC016066 · NIDCD · WASHINGTON UNIVERSITY · PI Lavinia Sheets · 2017 to 2026
$3.6M
Connectomics of relapse to aggression seekingR00DA045662 · NIDA · UNIVERSITY OF WASHINGTON · PI GOLDEN, SAM · 2019 to 2021
$736k
NIDA NIH HHS P30 DA048736NIDA NIH HHS R00 DA045662NIDCD NIH HHS R01 DC016066
6 · The paper itself

Abstract

The zebrafish lateral line is an established model for hair cell organ damage, yet few studies link mechanistic disruptions to changes in biologically relevant behavior. We used larval zebrafish to determine how damage via ototoxic compounds impact rheotaxis. Larvae were treated with CuSO

Indexed as

Lateral Line SystemZebrafishAnimalsHair Cells, AuditoryLarvaSwimming

Identifiers

PMID36681757
PMCPMC9867717
OpenAlexW4317663954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.