ArticleSignal transduction and targeted therapy2023
Application of metabolomics in urolithiasis: the discovery and usage of succinate.
Article in Signal transduction and targeted therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 34 citations in OpenAlex.
- Phenylalanine primes renal tubular redox vulnerability and calcium oxalate crystal retention through a PPARδ-CPT1A fatty-acid oxidation axis.Redox biology · 2026Article
- Gut Microbiota-Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1-Mediated Parthanatos.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Urinary volatilomics for biomarker discovery in kidney stone patients and healthy controls.Urolithiasis · 2026Article
- [Characteristics of urinary organic acid metabolic profile and screening of key metabolic markers in patients with urolithiasis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Animal models for calcium oxalate kidney stone research.Zoological research · 2026Review
- Dual-source CT for medical dissolution of uric acid stones: a retrospective derivation and prospective validation study.European journal of medical research · 2026Article
- Zwitterionic multifunctional coatings with strong hydration for ureteral stents to inhibit infectious encrustation.Bioactive materials · 2026Article
- Machine learning-driven multi-omics integration of urinary organic acids and ions enables precision risk stratification for calcium oxalate nephrolithiasis.Frontiers in medicine · 2026Article
- Identification of Biomarker in Kidney Stone Disease by Integrating Transcriptomics and Olink Proteomics: A Case-Control Study.Journal of inflammation research · 2026Article
- Article
- Noninvasive CT radiomics-clinical model accurately classifies anhydrous uric acid stones: a multicenter study.World journal of urology · 2025Article
- Comprehensive diagnostic evaluation of urolithiasis and cystitis in K9 dogs in Iraq: Clinical, laboratory, and imaging correlates.Open veterinary journal · 2025Article
- Genetically predicted blood metabolites mediate the association between immune cell characteristics and urolithiasis: A Mendelian randomization study and mediation analysis.Genes & diseases · 2025Article
- Effect of the plasma metabolites, biomarkers, and inflammatory proteins on urolithiasis: insights from Mendelian randomization and mediation analysis.Urolithiasis · 2025Article
- Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology.Acta pharmacologica Sinica · 2025Review
- Identification of the relationship between 1400 blood metabolites and urolithiasis: A bidirectional Mendelian randomization study.Medicine · 2025Article
- Kidney Stones as Minerals: How Methods from Geology Could Inform Urolithiasis Treatment.Journal of clinical medicine · 2025Review
- The effect of calcium oxalate stones and uric acid stones on male sexual function.International urology and nephrology · 2025Article
- Regulating the balance between GSDMD-mediated pyroptosis and CHMP4B-dependent cell repair attenuates calcium oxalate kidney stone formation.International journal of biological sciences · 2025Article
- A New Perspective on Gas Chromatography-Mass Spectrometry Urinary Metabolomic Analysis and Efficient Risk Assessment of Urolithiasis: Morning Urine Organic Acid Profiles.Kidney & blood pressure research · 2025Article
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) during stone formation is regulated by crystal growth modifiers. Although crystallization inhibitors have been recognized as a therapeutic modality for decades, limited progress has been made in the discovery of effective modifiers to intervene with stone disease. In this study, we have used metabolomics technologies, a powerful approach to identify biomarkers by screening the urine components of the dynamic progression in a bladder stone model. By in-depth mining and analysis of metabolomics data, we have screened five differential metabolites. Through density functional theory studies and bulk crystallization, we found that three of them (salicyluric, gentisic acid and succinate) could effectively inhibit nucleation in vitro. We thereby assessed the impact of the inhibitors with an EG-induced rat model for kidney stones. Notably, succinate, a key player in the tricarboxylic acid cycle, could decrease kidney calcium deposition and injury in the model. Transcriptomic analysis further showed that the protective effect of succinate was mainly through anti-inflammation, inhibition of cell adhesion and osteogenic differentiation. These findings indicated that succinate may provide a new therapeutic option for urinary stones.
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