Evidence map›Paper›PMID 36681388›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023

Prediction of neuropathologic lesions from clinical data.

Thanaphong Phongpreecha, Brenna Cholerton, Syed Bukhari, Alan L Chang, Davide De Francesco, Melan Thuraiappah, Dana Godrich, Amalia Perna, Martin G Becker, Neal G Ravindra and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Identifying dementia neuropathology using low-burden clinical data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. High rates of diagnostic discordance and co-pathology: Insights into PSP from the NACC dataset.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Thanaphong PhongpreechaDepartment of Pathology, Stanford University, Stanford, California, USA.ORCID 0000-0001-9245-6686
Brenna CholertonDepartment of Pathology, Stanford University, Stanford, California, USA.
Syed BukhariDepartment of Pathology, Stanford University, Stanford, California, USA.
Alan L ChangDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Davide De FrancescoDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Melan ThuraiappahDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Dana GodrichDr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.
Amalia PernaDepartment of Pathology, Stanford University, Stanford, California, USA.
Martin G BeckerDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Neal G RavindraDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Camilo EspinosaDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Yeasul KimDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Eloise BersonDepartment of Pathology, Stanford University, Stanford, California, USA.
Samson MatarasoDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Sharon J ShaDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, California, USA.
Edward J FoxDepartment of Pathology, Stanford University, Stanford, California, USA.
Kathleen S MontineDepartment of Pathology, Stanford University, Stanford, California, USA.
Laura D BakerDepartment of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, North Carolina, USA.
Suzanne CraftDepartment of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, North Carolina, USA.
Lon WhitePacific Health Research and Education Institute, Honolulu, Hawaii, USA.
Kathleen L PostonDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, California, USA.
Gary BeechamDr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.
Nima AghaeepourDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, California, USA.
Thomas J MontineDepartment of Pathology, Stanford University, Stanford, California, USA.

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0M
VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHIMMING, CORBETT · 1985 to 2019
$37.9M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
NIA NIH HHS P20 AG068024NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047270NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG062268NIA NIH HHS R01 AG062695NIA NIH HHS U01 AG079850NIA NIH HHS U24 AG072122NIA NIH HHS UF1 AG057707NIGMS NIH HHS R35 GM138353NIMH NIH HHS R01 MH120794NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

introductionPost-mortem analysis provides definitive diagnoses of neurodegenerative diseases; however, only a few can be diagnosed during life.

methodsThis study employed statistical tools and machine learning to predict 17 neuropathologic lesions from a cohort of 6518 individuals using 381 clinical features (Table S1). The multisite data allowed validation of the model's robustness by splitting train/test sets by clinical sites. A similar study was performed for predicting Alzheimer's disease (AD) neuropathologic change without specific comorbidities.

resultsPrediction results show high performance for certain lesions that match or exceed that of research annotation. Neurodegenerative comorbidities in addition to AD neuropathologic change resulted in compounded, but disproportionate, effects across cognitive domains as the comorbidity number increased. DISCUSSION: Certain clinical features could be strongly associated with multiple neurodegenerative diseases, others were lesion-specific, and some were divergent between lesions. Our approach could benefit clinical research, and genetic and biomarker research by enriching cohorts for desired lesions.

Indexed as

Alzheimer DiseaseBiomarkersComorbidityHumansNeuropathologyBiomarkersAlzheimer's disease neuropathologic changecomorbiditiesLewy body diseaseneuropsychological battery testspost-mortem autopsies

Identifiers

PMID36681388
PMCPMC10359434

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.