ArticleJournal of vascular surgery. Venous and lymphatic disorders2023
Different diagnostic strategies using D-dimer for peripherally inserted central catheter-related upper extremity deep vein thrombosis.
Article in Journal of vascular surgery. Venous and lymphatic disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Experience in treating thrombosis after adjustment of a PICC catheter.Radiology case reports · 2026Article
- Comparative safety outcomes of three venous access routes for totally implantable venous access port placement and exploratory assessment of pre-removal catheter-related thrombosis in breast cancer patients.Frontiers in oncology · 2026Article
- Effects of totally implantable venous access ports on complications and quality of life in gastrointestinal cancer chemotherapy.World journal of gastrointestinal surgery · 2025Article
- Catheter-related deep vein thrombosis: Where are we at and where are we going? Updates and ongoing unmet clinical needs.European journal of clinical investigation · 2025Review
- Risk factors for peripherally inserted central catheter-related venous thrombosis in adult patients with cancer.Thrombosis journal · 2024Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDeep vein thrombosis (DVT) in the upper extremities caused by a peripherally inserted central venous catheter (PICC) is distinct from the typical DVT. This specific type of mural thrombus might have an effect on the D-dimer levels. In the present study, we aimed to ascertain whether the D-dimer level might be considered an independent diagnostic marker to rule out upper extremity DVT caused by PICCs.
methodsWe performed a retrospective case-cohort study of 205 patients who had undergone D-dimer measurement and color Doppler ultrasound within 14 days after placement of a PICC to December 31, 2020, from January 1, 2018. The participants were followed up for 3 months to evaluate for upper extremity DVT. In addition, different D-dimer diagnostic strategies were analyzed.
resultsOf the 205 included patients, 53 (25.9%) had had a negative D-dimer level. Of the 53 patients, 10 had had upper extremity DVT attributable to a PICC using color Doppler ultrasound. Of these 10 patients, 3 had developed upper extremity DVT during the 3-month follow-up. Using the various D-dimer diagnostic techniques, the negative predictive value for the D-dimer levels was 81.1%.
conclusionsThe present study has shown that the different D-dimer diagnostic strategies are not effective for safely excluding the diagnosis of suspected PICC-related upper extremity DVT. Adding PICC placement as a special factor in the modified Wells score, in addition to the D-dimer level, could securely rule out PICC-related upper extremity DVT; however, the diagnostic efficacy was low.
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