Evidence map›Paper›PMID 36681134›Full record

ArticleNeuroImage2023

High-frequency neuronal signal better explains multi-phase BOLD response.

Qingqing Zhang, Samuel R Cramer, Kevin L Turner, Thomas Neuberger, Patrick J Drew, Nanyin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qingqing ZhangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, USA; Center for Neurotechnology in Mental Health Research, The Pennsylvania State University, University Park 16802, USA; Center for Neural Engineering, The Pennsylvania State University, University Park 16802, USA.
Samuel R CramerThe Neuroscience Graduate Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, USA; Center for Neurotechnology in Mental Health Research, The Pennsylvania State University, University Park 16802, USA; Center for Neural Engineering, The Pennsylvania State University, University Park 16802, USA.
Kevin L TurnerDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, USA; Center for Neurotechnology in Mental Health Research, The Pennsylvania State University, University Park 16802, USA; Center for Neural Engineering, The Pennsylvania State University, University Park 16802, USA.
Thomas NeubergerDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, USA; Center for Neurotechnology in Mental Health Research, The Pennsylvania State University, University Park 16802, USA.
Patrick J DrewDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, USA; The Neuroscience Graduate Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, USA; Center for Neurotechnology in Mental Health Research, The Pennsylvania State University, University Park 16802, USA; Center for Neural Engineering, The Pennsylvania State University, University Park 16802, USA; Departments of Engineering Science and Mechanics, Neurosurgery, and Biology, The Pennsylvania State University, University Park, USA.
Nanyin ZhangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, USA; The Neuroscience Graduate Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, USA; Center for Neurotechnology in Mental Health Research, The Pennsylvania State University, University Park 16802, USA; Center for Neural Engineering, The Pennsylvania State University, University Park 16802, USA. Electronic address: nuz2@psu.edu.
Pennsylvania State University · US

Funding

Resting-state Neural Networks in Awake RodentsR01NS085200 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI ZHANG, NANYIN · 2013 to 2024
$3.4M
Elucidating dynamic reorganization of whole-brain networks during anesthetic-induced unconsciousnessR01GM141792 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI ZHANG, NANYIN · 2021 to 2024
$1.3M
NIGMS NIH HHS R01 GM141792NINDS NIH HHS R01 NS085200
6 · The paper itself

Abstract

Visual stimulation-evoked blood-oxygen-level dependent (BOLD) responses can exhibit more complex temporal dynamics than a simple monophasic response. For instance, BOLD responses sometimes include a phase of positive response followed by a phase of post-stimulus undershoot. Whether the BOLD response during these phases reflects the underlying neuronal signal fluctuations or is contributed by non-neuronal physiological factors remains elusive. When presenting blocks of sustained (i.e. DC) light ON-OFF stimulations to unanesthetized rats, we observed that the response following a decrease in illumination (i.e. OFF stimulation-evoked BOLD response) in the visual cortices displayed reproducible multiple phases, including an initial positive BOLD response, followed by an undershoot and then an overshoot before the next ON trial. This multi-phase BOLD response did not result from the entrainment of the periodic stimulation structure. When we measured the neural correlates of these responses, we found that the high-frequency band from the LFP power (300 - 3000 Hz, multi-unit activity (MUA)), but not the power in the gamma band (30 - 100 Hz) exhibited the same multiphasic dynamics as the BOLD signal. This study suggests that the post-stimulus phases of the BOLD response can be better explained by the high-frequency neuronal signal.

Indexed as

Magnetic Resonance ImagingVisual CortexAnimalsBrain MappingEvoked Potentials, VisualNeuronsOxygenPhotic StimulationRatsOxygen

Identifiers

PMID36681134
PMCPMC9962576
OpenAlexW4317380929

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.