Evidence map›Paper›PMID 36681075›Full record

ArticleNeuron2023

Causal role of a neural system for separating and selecting multidimensional social cognitive information.

Ali Mahmoodi, Hamed Nili, Caroline Harbison, Sorcha Hamilton, Nadescha Trudel, Dan Bang, Matthew F S Rushworth

Open access · hybridAbstract read
In one paragraph

Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Fundamental features of social environments determine rate of social affiliation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ali MahmoodiWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, UK. Electronic address: ali.mahmoodi1367@gmail.com.
Hamed NiliWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, UK; Department of Excellence for Neural Information Processing, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Caroline HarbisonWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, UK.
Sorcha HamiltonWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, UK.
Nadescha TrudelWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, UK; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, UK; Wellcome Centre for Human Neuroimaging, University College London, Oxford, UK.
Dan BangWellcome Centre for Human Neuroimaging, University College London, Oxford, UK; Department of Experimental Psychology, University of Oxford, Oxford, UK; Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Matthew F S RushworthWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, UK.
University of Oxford · GBWellcome Centre for Human Neuroimaging · GBUniversität Hamburg · DE

Funding

Wellcome TrustWellcome Trust 203139/Z/16/ZWellcome Trust 203147/Z/16/ZWellcome Trust 213630/Z/18/ZWellcome Trust 221794/Z/20/ZWellcome Trust WT100973AIA
6 · The paper itself

Abstract

People are multi-faceted, typically good at some things but bad at others, and a critical aspect of social judgement is the ability to focus on those traits relevant for the task at hand. However, it remains unknown how the brain supports such context-dependent social judgement. Here, we examine how people represent multidimensional individuals, and how the brain extracts relevant information and filters out irrelevant information when comparing individuals within a specific dimension. Using human fMRI, we identify distinct neural representations in dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI) supporting separation and selection of information for context-dependent social judgement. Causal evaluation using non-invasive brain stimulation shows that AI disruption alters the impact of relevant information on social comparison, whereas dmPFC disruption only affects the impact of irrelevant information. This neural circuit is distinct from the one supporting integration across, as opposed to separation of, different features of a multidimensional cognitive space.

Indexed as

BrainPrefrontal CortexBrain MappingCognitionHumansJudgmentMagnetic Resonance Imaginganterior insulacognitive mapdorsomedial prefrontal cortexfMRImultidimensional social decision-makingnon-invasive brain stimulationTMS

Identifiers

PMID36681075
PMCPMC10914676
OpenAlexW4317708748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.