Evidence map›Paper›PMID 36681010›Full record

ArticleGynecologic oncology2023

Genetic variants associated with post-traumatic stress symptoms in patients with gynecologic cancer.

Andrea M Johnson, Deanna Teoh, Patricia Jewett, Burcu F Darst, Jordan Mattson, Cody Hoffmann, Katherine Brown, Aditi Makaram, Ciana Keller, Anne H Blaes and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrea M JohnsonUniversity of Minnesota, Department of Obstetrics, Gynecology and Women's Health, Minneapolis, MN, United States of America.
Deanna TeohUniversity of Minnesota, Department of Obstetrics, Gynecology and Women's Health, Minneapolis, MN, United States of America.
Patricia JewettUniversity of Minnesota, Department of Obstetrics, Gynecology and Women's Health, Minneapolis, MN, United States of America; University of Minnesota, Division of Hematology and Oncology, Minneapolis, MN, United States of America.
Burcu F DarstFred Hutchinson Cancer Center, Public Health Sciences, Seattle, WA, United States of America.
Jordan MattsonUniversity of Minnesota, Department of Obstetrics, Gynecology and Women's Health, Minneapolis, MN, United States of America.
Cody HoffmannUniversity of Minnesota Genomics Center, University of Minnesota, Minneapolis, MN, United States of America.
Katherine BrownUniversity of Minnesota, Department of Obstetrics, Gynecology and Women's Health, Minneapolis, MN, United States of America.
Aditi MakaramUniversity of Minnesota, College of Biological Sciences, Minneapolis, MN, United States of America.
Ciana KellerUniversity of Minnesota, Medical School, Minneapolis, MN, United States of America.
Anne H BlaesUniversity of Minnesota, Division of Hematology and Oncology, Minneapolis, MN, United States of America.
Susan A Everson-RoseUniversity of Minnesota, Division of Geriatrics, Palliative and Primary Care, Minneapolis, MN, United States of America.
Rachel I VogelUniversity of Minnesota, Department of Obstetrics, Gynecology and Women's Health, Minneapolis, MN, United States of America. Electronic address: isak0023@umn.edu.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1 TR002494NCI NIH HHS P30 CA077598
6 · The paper itself

Abstract

objectivePatients with cancer experience symptoms of post-traumatic stress disorder (PTSD) more commonly than the general population. The objective of this study was to identify single nucleotide polymorphisms (SNPs) associated with increased risk of post-traumatic stress disorder (PTSD) in patients with gynecologic cancer.

methodsA prospective cohort study recruited 181 gynecologic cancer survivors receiving care at the University of Minnesota between 2017 and 2020 who completed PTSD DSM-V surveys to self-report their symptoms of PTSD and provided saliva samples. DNA samples were genotyped for 11 SNPs in 9 genes involved in dopaminergic, serotonergic, and opioidergic systems previously associated with risk of PTSD in populations without cancer.

resultsMost participants had either ovarian (42.5%) or endometrial (46.4%) cancer; fewer had cervical (7.7%) or vaginal/vulvar (3.3%) cancer. Two SNPS were identified as statistically significantly associated with higher PTSD scores: rs622337 in HTR2A and rs510769 in OPRM1.

conclusionsGenetic variation likely plays a role in development of PTSD. HTR2A is involved in the serotonin pathway, and OPRM1 is involved in the opioid receptor pathway. This information can be used by oncologic providers to identify patients at greater risk of developing PTSD and may facilitate referral to appropriate consultants and resources early in their treatment.

Indexed as

Genital Neoplasms, FemaleStress Disorders, Post-TraumaticFemaleGenotypeHumansPolymorphism, Single NucleotideProspective StudiesCancer distressCancer survivorshipGynecologic cancerPTSD

Identifiers

PMID36681010
PMCPMC10023401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.