Evidence map›Paper›PMID 36680843›Full record

ArticlePsychiatry research. Neuroimaging2023

Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia.

Eun-Jin Cheon, Alie G Male, Bingchen Gao, Bhim M Adhikari, Jesse T Edmond, Stephanie M Hare, Aysenil Belger, Steven G Potkin, Juan R Bustillo, Daniel H Mathalon and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Neuroanatomical Correlates of Negative Symptoms in Schizophrenia.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 12 institutions in 2 countries.

Eun-Jin CheonClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States; Department of Psychiatry, Yeungnam University College of Medicine, Daegu, South Korea.
Alie G MaleClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
Bingchen GaoClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
Bhim M AdhikariMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.
Jesse T EdmondCenter for Translational Research in Neuroimaging and Data Science (TReNDS), GSU/GATech/Emory, Atlanta, GA, United States.
Stephanie M HareMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.
Aysenil BelgerDepartment of Psychiatry, University of North Carolina, Chapel Hill, United States.
Steven G PotkinDepartment of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
Juan R BustilloDepartments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM, United States.
Daniel H MathalonDepartment of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, United States; Veterans Affairs San Francisco Healthcare System, San Francisco, CA, United States.
Judith M FordDepartment of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, United States; Veterans Affairs San Francisco Healthcare System, San Francisco, CA, United States.
Kelvin O LimDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
Bryon A MuellerDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
Adrian PredaDepartment of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
Daniel O'LearyDepartment of Psychiatry, University of Iowa, IA, United States.
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, United States.
Anthony O AhmedDepartment of Psychiatry, Weill Cornell Medicine, White Plains, NY, United States.
Paul M ThompsonImaging Genetics Center, University of Southern California, Marina del Rey, CA, United States.
Neda JahanshadImaging Genetics Center, University of Southern California, Marina del Rey, CA, United States.
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.
Vince D CalhounCenter for Translational Research in Neuroimaging and Data Science (TReNDS), GSU/GATech/Emory, Atlanta, GA, United States.
Jessica A TurnerDepartment of Psychiatry, Ohio State University, OH, United States.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, United States. Electronic address: tvanerp@uci.edu.
University of California, Irvine · USUniversity of Maryland, Baltimore · USCenter for Translational Research in Neuroimaging and Data Science · USSan Francisco VA Medical Center · USUniversity of Minnesota · USUniversity of Southern California · USCornell University · USOhio University · USUniversity of Georgia · USUniversity of Iowa · USUniversity of New Mexico · USUniversity of North Carolina at Chapel Hill · US

Funding

FUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0M
BIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC)U24RR025736 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL · 2009 to 2011
$15.0M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
ENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0M
Multidisciplinary Schizophrenia Research TrainingT32MH067533 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CARPENTER, WILLIAM T., ELMER, GREGORY I · 2004 to 2025
$4.3M
Male/Female differences in psychosis and mood disorders:Dynamic imaging-genomic models for characterizing and predicting psychosis and mood dR01MH118695 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2019 to 2023
$3.8M
Lifespan Vascular Biology on White MatterRF1NS114628 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2020 to 2020
$3.1M
Redefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2M
Hybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593k
NCRR NIH HHS U24 RR021992NCRR NIH HHS U24 RR025736NIBIB NIH HHS R01 EB015611NIH HHS S10 OD023696NIMH NIH HHS R01 MH118695NIMH NIH HHS R01 MH121246NIMH NIH HHS RF1 MH123163NIMH NIH HHS T32 MH067533
6 · The paper itself

Abstract

This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

Indexed as

SchizophreniaAnhedoniaBrainHumansMood DisordersMotivationALFFAvolitionNegative symptoms

Identifiers

PMID36680843
PMCPMC11154089
OpenAlexW4316654763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.