Evidence map›Paper›PMID 36680783›Full record

ArticleAlcohol, clinical & experimental research2023

Associations of parent-adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder.

Gayathri Pandey, Sally I-Chun Kuo, Kristina A Horne-Osipenko, Ashwini K Pandey, Chella Kamarajan, Stacey Saenz de Viteri, Sivan Kinreich, David B Chorlian, Weipeng Kuang, Mallory Stephenson and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol, clinical & experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 1 country.

Gayathri PandeyDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.ORCID 0000-0003-0889-3117
Sally I-Chun KuoDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID 0000-0002-6192-1001
Kristina A Horne-OsipenkoDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.
Ashwini K PandeyDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.ORCID 0000-0002-2688-7901
Chella KamarajanDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.ORCID 0000-0003-2291-6880
Stacey Saenz de ViteriDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.
Sivan KinreichDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.
David B ChorlianDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.
Weipeng KuangDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.
Mallory StephensonDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID 0000-0002-1498-4333
John KramerDepartment of Psychiatry, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-1321-7087
Andrey AnokhinDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Yong ZangDepartment of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Samuel KupermanDepartment of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Victor HesselbrockDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.ORCID 0000-0002-0495-8641
Marc SchuckitDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-2323-7858
Danielle DickDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID 0000-0002-1636-893X
Grace ChanDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.ORCID 0000-0002-1257-6889
Vivia V McCutcheonDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-2694-5438
Howard EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-0344-9690
Kathleen K BucholzDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Jacquelyn L MeyersDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.
Bernice PorjeszDepartment of Psychiatry and Behavioral Sciences, State University of New York, Downstate Health Sciences University, New York, Brooklyn, USA.
State University of New York · USRutgers, The State University of New Jersey · USWashington University in St. Louis · USUniversity of Connecticut · USUniversity of Iowa · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineUniversity of California San Diego · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Brain Function and Neurogenomic influences on AUD risk and resilience.R01AA028848 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI KAMARAJAN, CHELLA, MEYERS, JACQUELYN LEIGH · 2021 to 2025
$2.6M
NIAAA NIH HHS R01 AA028848NIAAA NIH HHS U10 AA008401NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

backgroundParents impact their offspring's brain development, neurocognitive function, risk, and resilience for alcohol use disorder (AUD) via both genetic and socio-environmental factors. Individuals with AUD and their unaffected children manifest low parietal P3 amplitude and low frontal theta (FT) power, reflecting heritable neurocognitive deficits associated with AUD. Likewise, children who experience poor parenting tend to have atypical brain development and greater rates of alcohol problems. Conversely, positive parenting can be protective and critical for normative development of self-regulation, neurocognitive functioning and the neurobiological systems subserving them. Yet, the role of positive parenting in resiliency toward AUD is understudied and its association with neurocognitive functioning and behavioral vulnerability to AUD among high-risk offspring is less known. Using data from the Collaborative Study on the Genetics of Alcoholism prospective cohort (N = 1256, mean age [SD] = 19.25 [1.88]), we investigated the associations of closeness with mother and father during adolescence with offspring P3 amplitude, FT power, and binge drinking among high-risk offspring.

methodsSelf-reported closeness with mother and father between ages 12 and 17 and binge drinking were assessed using the Semi-Structured Assessment for the Genetics of Alcoholism. P3 amplitude and FT power were assessed in response to target stimuli using a Visual Oddball Task.

resultsMultivariate multiple regression analyses showed that closeness with father was associated with larger P3 amplitude (p = 0.002) and higher FT power (p = 0.01). Closeness with mother was associated with less binge drinking (p = 0.003). Among male offspring, closeness with father was associated with larger P3 amplitude, but among female offspring, closeness with mother was associated with less binge drinking. These associations remained statistically significant with father's and mothers' AUD symptoms, socioeconomic status, and offspring impulsivity in the model.

conclusionsAmong high-risk offspring, closeness with parents during adolescence may promote resilience for developing AUD and related neurocognitive deficits albeit with important sex differences.

Indexed as

AlcoholismBinge DrinkingAdolescentAlcohol DrinkingChildFemaleHumansMaleParentsProspective Studiesalcohol use disorderfrontal thetaP3 amplitudeparent-adolescent closeness

Identifiers

PMID36680783
PMCPMC10910630
OpenAlexW4317678634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.