Evidence map›Paper›PMID 36680617›Full record

Trial reportClinical research in cardiology : official journal of the German Cardiac Society2023

Prediction of conduction disturbances in patients undergoing transcatheter aortic valve replacement.

Valérie Pavlicek, Felix Mahfoud, Katharina Bubel, Peter Fries, Sebastian Ewen, Michael Böhm, Bruno Scheller, Christian Ukena

Registry-linked trialOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04128384 (Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04128384 naunknown statusnot on this map

Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block: Possible Predictors for High-grade AV Block Following Transcatheter Aortic Valve Replacement

TypeinterventionalSponsorUniversity Hospital, SaarlandRan2018 to 2023Enrolled200ConditionsSevere Aortic Valve Stenosis, High-degree AV Block, Left Bundle-Branch BlockArmsLimited electrophysiologic study including measurements of HV- and AH-intervals pre- and post-TAVR
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Valérie PavlicekKlinik Für Innere Medizin III, Kardiologie, Angiologie Und Internistische Intensivmedizin, Universitätsklinikum Des Saarlandes, Saarland University, Kirrberger Str, 66421, Homburg/Saar, Germany. valerie.pavlicek@uks.eu.ORCID http://orcid.org/0000-0002-3758-4586
Felix MahfoudKlinik Für Innere Medizin III, Kardiologie, Angiologie Und Internistische Intensivmedizin, Universitätsklinikum Des Saarlandes, Saarland University, Kirrberger Str, 66421, Homburg/Saar, Germany.
Katharina BubelKlinik Für Diagnostische Und Interventionelle Radiologie, Universitätsklinikum Des Saarlandes, Saarland University, Homburg/Saar, Germany.
Peter FriesKlinik Für Diagnostische Und Interventionelle Radiologie, Universitätsklinikum Des Saarlandes, Saarland University, Homburg/Saar, Germany.
Sebastian EwenKlinik Für Innere Medizin III, Kardiologie, Angiologie Und Internistische Intensivmedizin, Universitätsklinikum Des Saarlandes, Saarland University, Kirrberger Str, 66421, Homburg/Saar, Germany.
Michael BöhmKlinik Für Innere Medizin III, Kardiologie, Angiologie Und Internistische Intensivmedizin, Universitätsklinikum Des Saarlandes, Saarland University, Kirrberger Str, 66421, Homburg/Saar, Germany.
Bruno SchellerKlinik Für Innere Medizin III, Kardiologie, Angiologie Und Internistische Intensivmedizin, Universitätsklinikum Des Saarlandes, Saarland University, Kirrberger Str, 66421, Homburg/Saar, Germany.
Christian UkenaKlinik Für Innere Medizin III, Kardiologie, Angiologie Und Internistische Intensivmedizin, Universitätsklinikum Des Saarlandes, Saarland University, Kirrberger Str, 66421, Homburg/Saar, Germany.
Universitätsklinikum des Saarlandes · DEUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTranscatheter aortic valve replacement (TAVR) can cause intraventricular conduction disturbances (ICA), particularly left bundle branch block (BBB) and high-degree atrioventricular block (HAVB). The aim of this study was to investigate clinical, anatomical, procedural, and electrophysiological parameters predicting ICA after TAVR.

methodsPatients with severe aortic stenosis (n = 203) without pacing devices undergoing TAVR with a self-expanding (n = 103) or balloon-expanding (n = 100) valve were enrolled. Clinical and anatomical parameters, such as length of the membranous septum (MS) and implantation depth, were assessed. His-ventricular interval (HVi) before and after implantation was determined. 12-lead-electrocardiograms (ECG) before, during and after 3 and 30 days after TAVR were analyzed for detection of any ICA.

resultsAmong 203 consecutive patients (aortic valve area 0.78 ± 0.18 cm

conclusionsNew-onset left BBB and diabetes mellitus independently predicted HAVB requiring PPM after TAVR and helped to identify patients at risk. Electrophysiologic study (EPS) of atrioventricular conduction was neither specific nor predictive of HAVB and can be skipped. TRIAL REGISTRATION NUMBER: NCT04128384 ( https://www. CLINICALTRIALS: gov ).

Indexed as

Aortic Valve StenosisAtrioventricular BlockPacemaker, ArtificialTranscatheter Aortic Valve ReplacementAgedAged, 80 and overAortic ValveCardiac Pacing, ArtificialFemaleHumansMaleRisk FactorsStroke VolumeTreatment OutcomeVentricular Function, LeftConduction disturbancesTranscatheter valve replacement

Identifiers

PMID36680617
PMCPMC10160192
OpenAlexW4317660885

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.