Evidence map›Paper›PMID 36680498›Full record

ArticleAutism : the international journal of research and practice2023

Sex differences in the course of autistic and co-occurring psychopathological symptoms in adolescents with and without autism spectrum disorder.

Ernst Horwitz, Melissa Vos, Annelies De Bildt, Kirstin Greaves-Lord, Nanda Rommelse, Robert Schoevers, Catharina Hartman

Open access · greenAbstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Executive function challenges persist into young adulthood and predict mental health outcomes in autism.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  3. Adaptive Functioning, Sensory Processing, and Behavioral Problems in Autistic Children: The Moderating Role of Gender.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  4. Sex Differences in Psychopathology and Neurocognition in Community Youth With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Trajectory of Irritability in Autistic and Typically Developing Youth From Early Childhood to Adolescence.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Decoding the genetic landscape of autism: A comprehensive review.World journal of clinical pediatrics · 2024
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ernst HorwitzGGZ Friesland, The Netherlands.ORCID 0000-0002-9204-1162
Melissa VosUniversity Medical Center Groningen, The Netherlands.
Annelies De BildtUniversity Medical Center Groningen, The Netherlands.
Kirstin Greaves-LordErasmus Medical Center Rotterdam, The Netherlands.
Nanda RommelseKarakter Child and Adolescent Psychiatry University Centre, The Netherlands.
Robert SchoeversUniversity Medical Center Groningen, The Netherlands.
Catharina HartmanUniversity Medical Center Groningen, The Netherlands.
University Medical Center Groningen · NLErasmus MC · NLGGZ Friesland · NLKarakter · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

lay abstractThere is an ongoing debate as to whether autism spectrum disorder (ASD) is expressed differently in women than men. Studies on sex differences in autistic symptoms and symptoms of other psychiatric problems present in individuals with autism generally do not include a general population comparison group, making it unclear whether differences are specific to autism or merely reflecting development in the general population. In this study, we compared sex differences in the course of autistic and at the same time present symptoms of other psychiatric problems in adolescents with milder forms of ASD to those in a group of the general population with an equal intelligence quotient (IQ) and socioeconomic status. Data of five assessment moments from ages 11 to 22 years were analyzed using a statistic procedure that allowed us to determine which factors affect the course of symptoms over time. We found that in adolescence, sex differences in the course of psychopathological symptoms specific for autism are confined to the repetitive stereotyped domains. Males had higher scores on the sensory/stereotypic and resistance to change domains, the latter difference disappeared during the course of adolescence due to an increase of these problems in autistic females. Other sex differences, among which an increase over time in mood and anxiety problems in females was the most outstanding, were also observed in females without autism. These sex-specific differences have relevance in the clinical care of autistic men and women, although they are subtle compared to differences between individuals with and without autism.

Indexed as

Autism Spectrum DisorderAutistic DisorderAdolescentFemaleHumansLongitudinal StudiesMaleSex CharacteristicsStereotyped Behavioradolescentsautism spectrum disorderscoursepsychiatric comorbiditysex differences

Identifiers

PMID36680498
PMCPMC10375001
OpenAlexW4317659128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.