Evidence map›Paper›PMID 36680312›Full record

ArticleBJU international2023

Diagnosis, treatment and survival from bladder, upper urinary tract, and urethral cancers: real-world findings from NHS England between 2013 and 2019.

James W F Catto, Olena Mandrik, Lewis A Quayle, Syed A Hussain, John McGrath, Joanne Cresswell, Alison J Birtle, Rob J Jones, Paramananthan Mariappan, Lydia E Makaroff and 5 more

Abstract read
In one paragraph

Article in BJU international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

James W F CattoDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.ORCID 0000-0003-2787-8828
Olena MandrikHealth Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield, UK.ORCID 0000-0003-3755-3031
Lewis A QuayleDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Syed A HussainDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
John McGrathDepartment of Urology, Royal Devon University Hospitals Foundation Trust, University of Exeter, Exeter, UK.ORCID 0000-0001-9416-9912
Joanne CresswellSouth Tees NHS Hospitals Trust, Middlesborough, UK.
Alison J BirtleRosemere Cancer Centre, Lancashire Teaching Hospitals, Preston, UK.
Rob J JonesSchool of Cancer Sciences, Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK.
Paramananthan MariappanDepartment of Urology, Edinburgh Bladder Cancer Surgery, Western General Hospital, Edinburgh, UK.ORCID 0000-0001-8221-4640
Lydia E MakaroffFight Bladder Cancer, Oxfordshire, UK.ORCID 0000-0001-7381-5743
Allen KnightPatient and Trustee, Action Bladder Cancer UK, Guildford, UK.
Hugh MostafidDepartment of Urology, The Royal Surrey County Hospital, Guildford, UK.ORCID 0000-0002-5095-2929
Jim ChilcottHealth Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield, UK.
Peter SasieniSchool of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
Marcus CumberbatchDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

Funding

Cancer Research UK 25356Cancer Research UK 27047
6 · The paper itself

Abstract

objectiveWe report NHS England data for patients with bladder cancer (BC), upper tract urothelial cancer (UTUC: renal pelvic and ureteric), and urethral cancers from 2013 to 2019. MATERIALS AND

methodsHospital episode statistics, waiting times, and cancer registrations were extracted from NHS Digital.

resultsRegistrations included 128 823 individuals with BC, 16 018 with UTUC, and 2533 with urethral cancer. In 2019, 150 816 persons were living with a diagnosis of BC, of whom 113 067 (75.0%) were men, 85 117 (56.5%) were aged >75 years, and 95 553 (91.7%) were Caucasian. Incidence rates were stable (32.7-34.3 for BC, 3.9-4.2 for UTUC and 0.6-0.7 for urethral cancer per 100 000 population). Most patients 52 097 (mean [range] 41.3% [40.7-42.0%]) were referred outside the 2-week-wait pathway and 15 340 (mean [range] 12.2% [11.7-12.6%]) presented as emergencies. Surgery, radiotherapy, chemotherapy, or multimodal treatment use varied with disease stage, patient factors and Cancer Alliance. Between 27% and 29% (n = 6616) of muscle-invasive BCs did not receive radical treatment. Survival rates reflected stage, grade, location, and tumour histology. Overall survival rates did not improve over time (relative change: 0.97, 95% confidence interval 0.97-0.97) at 2 years in contrast to other cancers.

conclusionThe diagnostic pathway for BC needs improvement. Increases in survival might be delivered through greater use of radical treatment. NHS Digital data offers a population-wide picture of this disease but does not allow individual outcomes to be matched with disease or patient features and key parameters can be missing or incomplete.

Indexed as

Carcinoma, Transitional CellUreteral NeoplasmsUrethral NeoplasmsUrinary Bladder NeoplasmsAgedFemaleHumansKidney PelvisMaleRetrospective StudiesState MedicineUrinary Bladderbladder cancercancer outcomeNHS statisticsurothelial cell carcinoma

Identifiers

PMID36680312
PMCPMC10952282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.