Evidence map›Paper›PMID 36680287›Full record

ArticleViruses2023

Exploring the Expression and Function of cTyro3, a Candidate Zika Virus Receptor, in the Embryonic Chicken Brain and Inner Ear.

Vashi Negi, Richard J Kuhn, Donna M Fekete

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vashi NegiDepartment of Biological Sciences, Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47906, USA.ORCID 0000-0001-9646-0025
Richard J KuhnDepartment of Biological Sciences, Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47906, USA.
Donna M FeketeDepartment of Biological Sciences, Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47906, USA.ORCID 0000-0003-0662-0246
Purdue University West Lafayette · US

Funding

Structural Studies of TogavirusesR01AI095366 · NIAID · PURDUE UNIVERSITY · PI KUHN, RICHARD J. · 2012 to 2023
$6.8M
DEVELOPMENT STUDIES OF THE INNER EARR01DC002756 · NIDCD · PURDUE UNIVERSITY WEST LAFAYETTE · PI FEKETE, DONNA M · 1995 to 2019
$6.8M
Laser Scanning Confocal MicroscopeS10RR023734 · NCRR · PURDUE UNIVERSITY · PI FEKETE, DONNA M · 2010 to 2010
$500k
Zika Virus Cell Tropism and Pathogenesis in the Developing Inner EarR21DC016732 · NIDCD · PURDUE UNIVERSITY · PI FEKETE, DONNA M · 2017 to 2018
$406k
NCRR NIH HHS S10 RR023734NIAID NIH HHS R01 AI095366NIDCD NIH HHS R01 DC002756NIDCD NIH HHS R21 DC016732
6 · The paper itself

Abstract

The transmembrane protein Axl was proposed as an entry receptor for Zika virus (ZIKV) infection in vitro, but conflicting results from in vivo studies have made it difficult to establish Axl as a physiologically relevant ZIKV receptor. Both the functional redundancy of receptors and the experimental model used can lead to variable results. Therefore, it can be informative to explore alternative animal models to analyze ZIKV receptor candidates as an aid in discovering antivirals. This study used chicken embryos to examine the role of chicken Tyro3 (cTyro3), the equivalent of human Axl. Results show that endogenous

Indexed as

Ear, InnerZika VirusZika Virus InfectionAnimalsAxl Receptor Tyrosine KinaseBrainChick EmbryoChickensHumansProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, VirusVirus ReplicationAxl Receptor Tyrosine KinaseProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, VirusAxlbasilar papillaneural tubeotocystTyro3Zika

Identifiers

PMID36680287
PMCPMC9867072
OpenAlexW4316465062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.