Evidence map›Paper›PMID 36680281›Full record

ArticleViruses2023

Evolutionary Origin, Genetic Recombination, and Phylogeography of Porcine Kobuvirus.

Yongqiu Cui, Jingyi Li, Jinshuo Guo, Yang Pan, Xinxin Tong, Changzhe Liu, Dedong Wang, Weiyin Xu, Yongyan Shi, Ying Ji and 7 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Prevalence and Genomic Features of Aichivirus D in Yaks in Western China.Animals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Identification of Recombinant Aichivirus D in Cattle, Italy.Animals : an open access journal from MDPI · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Yongqiu CuiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-3459-7047
Jingyi LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jinshuo GuoCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yang PanCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Xinxin TongCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Changzhe LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Dedong WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Weiyin XuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yongyan ShiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Ying JiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yonghui QiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Xiaoyu YangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Lei HouCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jianwei ZhouCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Xufei FengCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yong WangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Jue LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yangzhou University · CNAnhui Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The newly identified porcine Kobuvirus (PKV) has raised concerns owing to its association with diarrheal symptom in pigs worldwide. The process involving the emergence and global spread of PKV remains largely unknown. Here, the origin, genetic diversity, and geographic distribution of PKV were determined based on the available PKV sequence information. PKV might be derived from the rabbit Kobuvirus and sheep were an important intermediate host. The most recent ancestor of PKV could be traced back to 1975. Two major clades are identified, PKVa and PKVb, and recombination events increase PKV genetic diversity. Cross-species transmission of PKV might be linked to interspecies conserved amino acids at 13-17 and 25-40 residue motifs of Kobuvirus VP1 proteins. Phylogeographic analysis showed that Spain was the most likely location of PKV origin, which then spread to pig-rearing countries in Asia, Africa, and Europe. Within China, the Hubei province was identified as a primary hub of PKV, transmitting to the east, southwest, and northeast regions of the country. Taken together, our findings have important implications for understanding the evolutionary origin, genetic recombination, and geographic distribution of PKV thereby facilitating the design of preventive and containment measures to combat PKV infection.

Indexed as

KobuvirusPicornaviridae InfectionsSwine DiseasesAnimalsPhylogenyPhylogeographyRabbitsRecombination, GeneticSheepSwineevolutionary origingenetic recombinationphylodynamic analysesphylogeographyporcine kobuvirus

Identifiers

PMID36680281
PMCPMC9867129
OpenAlexW4316465158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.