Evidence map›Paper›PMID 36680252›Full record

ArticleViruses2023

Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands.

Reina S Sikkema, Erwin de Bruin, Christian Ramakers, Robbert Bentvelsen, Wentao Li, Berend-Jan Bosch, Brenda Westerhuis, Bart Haagmans, Marion P G Koopmans, Pieter L A Fraaij

Abstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Impact of COVID-19 Nonpharmaceutical Interventions onOpen forum infectious diseases · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Reina S SikkemaViroscience, Erasmus MC, 3015 Rotterdam, The Netherlands.ORCID 0000-0001-7331-6274
Erwin de BruinViroscience, Erasmus MC, 3015 Rotterdam, The Netherlands.
Christian RamakersClinical Chemistry, Erasmus MC, 3015 Rotterdam, The Netherlands.
Robbert BentvelsenMicrovida Laboratory for Microbiology, Amphia Hospital, 4818 Breda, The Netherlands.ORCID 0000-0002-9958-2842
Wentao LiInfectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 Utrecht, The Netherlands.ORCID 0000-0002-7114-762X
Berend-Jan BoschInfectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 Utrecht, The Netherlands.
Brenda WesterhuisViroscience, Erasmus MC, 3015 Rotterdam, The Netherlands.
Bart HaagmansViroscience, Erasmus MC, 3015 Rotterdam, The Netherlands.ORCID 0000-0001-6221-2015
Marion P G KoopmansViroscience, Erasmus MC, 3015 Rotterdam, The Netherlands.ORCID 0000-0002-5204-2312
Pieter L A FraaijViroscience, Erasmus MC, 3015 Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 prevention and control measures did not only impact SARS-CoV-2 circulation, but also the timing and prevalence of other seasonal respiratory viruses. Especially in children, information on exposure and infections to seasonal coronaviruses as well as SARS-CoV-2 in the first year of the pandemic is largely lacking. Therefore, we set up a one-year serological survey in a large tertiary hospital in the Netherlands. We show that seasonal coronavirus seroprevalence significantly decreased in 2021 in children less than one year, most likely due to COVID-19 control measures. The SARS-CoV-2 seroprevalence in children and adolescents increased from 0.4% to 11.3%, the highest in adolescents. This implies higher exposure rates in adolescents as compared to the general population (>18 years old). It is clear that there have been significant changes in the circulation and subsequent immunity against most respiratory pathogens as a result of the mitigation measures. The implications on shorter as well as longer term are still largely unknown, but the impact of the SARS-CoV-2 pandemic and subsequent control measures will continue to affect the dynamics of other pathogens.

Indexed as

COVID-19AdolescentAntibodies, ViralAntibody FormationChildHumansNetherlandsSARS-CoV-2SeasonsSeroepidemiologic StudiesAntibodies, ViralantibodieschildrenCOVID-19seasonal coronavirusserosurvey

Identifiers

PMID36680252
PMCPMC9862716

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.