Evidence map›Paper›PMID 36680203›Full record

ArticleViruses2023

Using Wastewater Surveillance to Compare COVID-19 Outbreaks during the Easter Holidays over a 2-Year Period in Cape Town, South Africa.

Nomfundo Mahlangeni, Renée Street, Suranie Horn, Angela Mathee, Noluxabiso Mangwana, Stephanie Dias, Jyoti Rajan Sharma, Pritika Ramharack, Johan Louw, Tarylee Reddy and 7 more

Abstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Environmental surveillance of pathogens in Africa.Applied and environmental microbiology · 2026
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nomfundo MahlangeniEnvironment & Health Research Unit, South African Medical Research Council (SAMRC), Johannesburg 2028, South Africa.ORCID 0000-0001-8655-2794
Renée StreetEnvironment & Health Research Unit, South African Medical Research Council (SAMRC), Johannesburg 2028, South Africa.
Suranie HornOccupational Hygiene and Health Research Initiative, North-West University, Potchefstroom 2531, South Africa.
Angela MatheeEnvironment & Health Research Unit, South African Medical Research Council (SAMRC), Johannesburg 2028, South Africa.ORCID 0000-0002-0060-829X
Noluxabiso MangwanaBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Stephanie DiasBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.ORCID 0000-0003-3008-4279
Jyoti Rajan SharmaBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.ORCID 0000-0003-0170-7342
Pritika RamharackBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Johan LouwBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Tarylee ReddyBiostatistics Research Unit, South African Medical Research Council (SAMRC), Durban 4091, South Africa.
Swastika Surujlal-NaickerScientific Services, Water and Sanitation Department, City of Cape Town Metropolitan Municipality, Cape Town 8000, South Africa.ORCID 0000-0002-1081-8549
Sizwe NkambuleEnvironment & Health Research Unit, South African Medical Research Council (SAMRC), Johannesburg 2028, South Africa.
Candice WebsterEnvironment & Health Research Unit, South African Medical Research Council (SAMRC), Johannesburg 2028, South Africa.
Mongezi MdhluliChief Research Operations Office, South African Medical Research Council (SAMRC), Tygerberg 7050, South Africa.
Glenda GrayOffice of the President, South African Medical Research Council (SAMRC), Tygerberg 7050, South Africa.
Christo MullerBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.ORCID 0000-0001-6821-2120
Rabia JohnsonBiomedical Research and Innovation Platform (BRIP), South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.ORCID 0000-0002-6328-0789

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wastewater surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown to be an important approach to determine early outbreaks of infections. Wastewater-based epidemiology (WBE) is regarded as a complementary tool for monitoring SARS-CoV-2 trends in communities. In this study, the changes in the SARS-CoV-2 RNA levels in wastewater during Easter holidays in 2021 and 2022 in the City of Cape Town were monitored over nine weeks. Our findings showed a statistically significant difference in the SARS-CoV-2 RNA viral load between the study weeks over the Easter period in 2021 and 2022, except for study week 1 and 4. During the Easter week, 52% of the wastewater treatment plants moved from the lower (low viral RNA) category in 2021 to the higher (medium to very high viral RNA) categories in 2022. As a result, the median SARS-CoV-2 viral loads where higher during the Easter week in 2022 than Easter week in 2021 (p = 0.0052). Mixed-effects model showed an association between the SARS-CoV-2 RNA viral loads and Easter week over the Easter period in 2021 only (p < 0.01). The study highlights the potential of WBE to track outbreaks during the holiday period.

Indexed as

COVID-19HolidaysHumansRNA, ViralSARS-CoV-2South AfricaWastewaterWastewater-Based Epidemiological MonitoringRNA, ViralWastewaterEaster holidaysSARS-CoV-2wastewater surveillancewastewater treatment plants

Identifiers

PMID36680203
PMCPMC9863979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.