Evidence map›Paper›PMID 36679999›Full record

ArticleVaccines2023

Ageing Curtails the Diversity and Functionality of Nascent CD8

Davide Proietto, Beatrice Dallan, Eleonora Gallerani, Valentina Albanese, Sian Llewellyn-Lacey, David A Price, Victor Appay, Salvatore Pacifico, Antonella Caputo, Francesco Nicoli and 1 more

Abstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The characterization of CD8Emerging microbes & infections · 2024
    Review
  3. Article
  4. Increased levels of GM-CSF and CXCL10 and low CD8Immunity & ageing : I & A · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Davide ProiettoDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44123 Ferrara, Italy.ORCID 0000-0002-3507-833X
Beatrice DallanDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44123 Ferrara, Italy.
Eleonora GalleraniDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44123 Ferrara, Italy.
Valentina AlbaneseDepartment of Environment and Prevention Sciences, University of Ferrara, 44123 Ferrara, Italy.
Sian Llewellyn-LaceyDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.ORCID 0000-0001-9416-2737
Victor AppayUniversité de Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.
Salvatore PacificoDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44123 Ferrara, Italy.
Antonella CaputoDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44123 Ferrara, Italy.ORCID 0000-0002-1241-0299
Francesco NicoliDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44123 Ferrara, Italy.ORCID 0000-0001-6327-5958
Riccardo GavioliDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44123 Ferrara, Italy.

Funding

Ludwig-Maximilians-Universität München One Health TARGET ProjectUniversity of Ferrara Bando Anno 2020 per Progetti di Ricerca Finanziati con il Contributo 5x1000 Anno 2018
6 · The paper itself

Abstract

Age-related changes in the immune system are thought to underlie the vulnerability of elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully validated

Indexed as

CD8+ T cellsimmunosenescenceSARS-CoV-2

Identifiers

PMID36679999
PMCPMC9867380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.